1. Sources of DNA Contamination in the Laboratory

    Sources of DNA Contamination in the Laboratory
    The polymerase chain reaction (PCR) technique, used to amplify or “copy” small segments of DNA, is highly sensitive - and that’s a good thing. PCR is a widely used and inexpensive technique used in medical diagnostics, forensic analysis of DNA, and genomic research. Unfortunately, this sensitivity leaves PCR vulnerable to nucleic acid contamination: even trace amounts of DNA can be...
  2. 7 Sources of Antibiotic Resistance

    7 Sources of Antibiotic Resistance
    The growing increase of antibiotic resistance is now a global problem. According to the National Foundation for Infectious Disease, approximately 3 million people each year struggle with infections from antibiotic resistant bacteria. About 35,000 individuals will die as a result of these infections. Antibiotic resistance is a concern for several important reasons. Illnesses such as strep throat, tuberculosis, and certain...
  3. Popular Anti-Fungal Drugs: An Overview

    Popular Anti-Fungal Drugs: An Overview
    Anti-fungal drugs play an important role in treating serious medical conditions. These drugs are used to treat primary fungal infections as well as secondary infections. Anti-fungal drugs can be administered through different channels and play a key role in keeping cancer patients and organ donors healthy. Let's examine how these drugs work and why continued research and development is so...
  4. PMSF: Serine Protease Inhibitor Applications

    PMSF: Serine Protease Inhibitor Applications
    Understanding PMSF PMSF (phenylmethylsulfonyl fluoride) is an irreversible serine protease inhibitor used in various research and lab settings. The compound has a white powdery appearance at room temperature, with a melting point between 90-95°C. It functions by inhibiting serine proteases such as trypsin, chymotrypsin, and thrombin, and cysteine proteases like papain. The process involves the deactivation of enzymes that contain...
  5. Nanopore Electrochemistry: Single-Molecule Sensors

    Nanopore Electrochemistry: Single-Molecule Sensors
    A trend in modern scientific research over the past decade is using smaller & smaller methods of studying targets, like molecules. Independent, smaller devices, and less expensive methods allow more access for researchers across the board, regardless of their space and budget. One such analytical method is the creation of artificial nanopore sensors for research using nanopore electrochemistry. Capturing reactions...
  6. Using Bicyclomycin to Treat Drug-Resistant Bacterial Infections

    Using Bicyclomycin to Treat Drug-Resistant Bacterial Infections
    Stating that antibiotics, first discovered in 1928 and commercially used by the 1940s, brought an unprecedented change to the world is not an overstatement. For decades now we have routinely cured illnesses and infections that were previously life-threatening. In recent years, however, bacterial infections have increasingly grown resistant to antibiotics. According to the CDC, approximately 2.8 million people each year...
  7. The SUnSET Assay: Powerful Proteomics

    The SUnSET Assay: Powerful Proteomics
    The SUnSET Assay: Powerful Proteomics Exciting advances in the study of protein synthesis and related health conditions are on the horizon! Research scientists have developed an improved process to quantify and understand the processes of protein synthesis in singular eukaryotic cells/cell populations. It’s called the surface sensing of translation, or SUnSET assay. It is a nonradioactive fluorescence-activated assay, which means...
  8. Amphotericin B for Viral Disease Research

    Amphotericin B for Viral Disease Research
    Amphotericin B for Viral Disease Research Amphotericin B is an antibiotic that has been used for over fifty years as an aggressive and effective antifungal treatment.  It battles serious fungal infections like cryptococcal meningitis with ease.  Often called by its brand name, Fungizone, this antibiotic is effective in saving lives and has been relied upon for decades because pathogens have...
  9. Pathology Research Using Mitophagy Modulators

    Pathology Research Using Mitophagy Modulators
    Pathology Research Using Mitophagy Modulators When you hear “small things with big impact”, do you immediately think of mitochondria and mitophagy modulators? Probably not! But these little organelles are champions of cell regulation.  Among their functions is regulating the energy of the cell as well as cell death. And just as mitochondria are responsible for cell function, mitophagy is responsible...
  10. Hydroxychloroquine: Misconceptions in the Media

    Hydroxychloroquine: Misconceptions in the Media
    Hydroxychloroquine: Misconceptions in the Media It’s hard to miss hearing the word “hydroxychloroquine” being associated with coronavirus in the news right now.  Hydroxychloroquine is being touted as a “game changer” in treating coronavirus by people in the current US administration who are not medical professionals. This drug has a similar structure to a previously established drug called CQ (N4-(7-Chloro-4-quinolinyl)-N1,N1-diethyl-1,4-pentanediamine), which...

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