1. Mitomycin C Applications in Life Sciences

    Mitomycin C Applications in Life Sciences
    Mitomycin C (C15H18N4O5) is a chemical product derived from Streptomyces caespitosus, an actinobacteria species. It appears as a blue-violet crystal or powder at room temperature. The product is soluble in water and rapidly degrades in acidic preparations. Healthcare researchers and scientists have studied and applied mitomycin C in cancer treatment for its antitumor properties. Mitomycin has become a popular chemotherapeutic...
  2. Top 10 Antibiotic Resistant Infections

    Top 10 Antibiotic Resistant Infections
    Antibiotic resistant infections arise when bacteria and other microbes develop immunity against the drugs administered against them. Infections involving antibiotic-resistant strains grow stronger over time and become increasingly difficult to treat. According to CDC reports, over 2.8 million antibiotic-resistant infections occur in the US every year and have lead to a large number of fatalities. Bacteria naturally develop immunities over...
  3. Cibacron Blue Applications

    Cibacron Blue Applications
    Cibacron Blue 3GA is a textile dye or ligand frequently used as a medium for affinity chromatography experiments, specifically for the purification of enzymes. The ligand appears as a blue powder under room temperature settings. Scientists and researchers commonly choose the compound for its affordability, ease of immobilization, high resistance against biological and chemical degradation, and high protein-binding capacity of...
  4. In Vitro Mutagenesis for Genetic Research

    In Vitro Mutagenesis for Genetic Research
    Scientists and researchers turn to cloned DNA for various breakthrough studies as they provide multiple genetic copies and DNA segments suitable for wide-scale tests. In vitro mutagenesis is one useful application of cloned DNA, where researchers create a mutation in one segment of the target DNA. The cloned DNA is then transferred into a cell or organism and studied, which provides...
  5. Sources of DNA Contamination in the Laboratory

    Sources of DNA Contamination in the Laboratory
    The polymerase chain reaction (PCR) technique, used to amplify or “copy” small segments of DNA, is highly sensitive - and that’s a good thing. PCR is a widely used and inexpensive technique used in medical diagnostics, forensic analysis of DNA, and genomic research. Unfortunately, this sensitivity leaves PCR vulnerable to nucleic acid contamination: even trace amounts of DNA can be...
  6. 7 Sources of Antibiotic Resistance

    7 Sources of Antibiotic Resistance
    The growing increase of antibiotic resistance is now a global problem. According to the National Foundation for Infectious Disease, approximately 3 million people each year struggle with infections from antibiotic resistant bacteria. About 35,000 individuals will die as a result of these infections. Antibiotic resistance is a concern for several important reasons. Illnesses such as strep throat, tuberculosis, and certain...
  7. Popular Anti-Fungal Drugs: An Overview

    Popular Anti-Fungal Drugs: An Overview
    Anti-fungal drugs play an important role in treating serious medical conditions. These drugs are used to treat primary fungal infections as well as secondary infections. Anti-fungal drugs can be administered through different channels and play a key role in keeping cancer patients and organ donors healthy. Let's examine how these drugs work and why continued research and development is so...
  8. PMSF: Serine Protease Inhibitor Applications

    PMSF: Serine Protease Inhibitor Applications
    Understanding PMSF PMSF (phenylmethylsulfonyl fluoride) is an irreversible serine protease inhibitor used in various research and lab settings. The compound has a white powdery appearance at room temperature, with a melting point between 90-95°C. It functions by inhibiting serine proteases such as trypsin, chymotrypsin, and thrombin, and cysteine proteases like papain. The process involves the deactivation of enzymes that contain...
  9. Nanopore Electrochemistry: Single-Molecule Sensors

    Nanopore Electrochemistry: Single-Molecule Sensors
    A trend in modern scientific research over the past decade is using smaller & smaller methods of studying targets, like molecules. Independent, smaller devices, and less expensive methods allow more access for researchers across the board, regardless of their space and budget. One such analytical method is the creation of artificial nanopore sensors for research using nanopore electrochemistry. Capturing reactions...
  10. Using Bicyclomycin to Treat Drug-Resistant Bacterial Infections

    Using Bicyclomycin to Treat Drug-Resistant Bacterial Infections
    Stating that antibiotics, first discovered in 1928 and commercially used by the 1940s, brought an unprecedented change to the world is not an overstatement. For decades now we have routinely cured illnesses and infections that were previously life-threatening. In recent years, however, bacterial infections have increasingly grown resistant to antibiotics. According to the CDC, approximately 2.8 million people each year...

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