1. Fighting Biofilm Formation

    Fighting Biofilm Formation
    Biofilm consists of bacterial colonies that excrete a sticky organic texture. The colonies form when a thin layer of microorganisms and proteins adhere to a surface. They may appear as a slimy film on poorly maintained poolsides, river rocks, dishes, and countertops or, in smaller forms, may be invisible to the eye. Biofilm Formation Specifically, biofilms form when groups of...
  2. SPRI Magnetic Beads for DNA Purification

    SPRI Magnetic Beads for DNA Purification
    Solid Phase Reversible Immobilization (SPRI) is a technique applied in high-performance isolation, purification, and cleanup procedures. The process uses SPRI magnetic beads by selectively binding nucleic acids (involving RNA and DNA) found in all organisms. Researchers discovered SPRI in 1995 at the Whitehouse Institute for the isolation of PCR products. Specifically, the experiment focused on purifying PCR amplified colonies in...
  3. Applications of Boric Acid

    Applications of Boric Acid
    Boric acid (H3BO3), also known as hydrogen borate or boracic acid, is a weak monobasic Lewis acid of boron. Researchers may increase the acidity of boric acid through complexation reactions with polyols like sorbitol or lactitol. The compound has multiple purposes, such as applications for molecular biology in buffer preparations. German chemist Wilhelm Homberg discovered man-made boric acid crystals in...
  4. Fidaxomicin for Life Science Research

    Fidaxomicin for Life Science Research
    Fidaxomicin (C52H74Cl2O18) is a member of the class of narrow spectrum macrocyclic antibiotics known as tiacumicins. The drug derives from the fermentation of tiacumicin metabolites from a soil isolate of the actinomycete Dactylosporangium aurantiacum, a Gram-positive bacterium. Scientists discovered fidaxomicin (known as lipiarmycin) in 1975, isolating the compound in pure form from Actinoplanes deccanensis. Researchers noted the antibiotic’s effectiveness in...
  5. Protease Inhibitors for COVID-19 Rapid Testing

    Protease Inhibitors for COVID-19 Rapid Testing
    The SARS-CoV-2 coronavirus was discovered in China in December 2019. Since then, more than two million people have died from COVID, including over 400,000 in the U.S. alone. COVID-19 rapid testing has become crucial because even in the absence of symptoms, people need to know if they're at risk of spreading the virus. People who test positive via a COVID-19 rapid test...
  6. Mitomycin C Applications in Life Sciences

    Mitomycin C Applications in Life Sciences
    Mitomycin C (C15H18N4O5) is a chemical product derived from Streptomyces caespitosus, an actinobacteria species. It appears as a blue-violet crystal or powder at room temperature. The product is soluble in water and rapidly degrades in acidic preparations. Healthcare researchers and scientists have studied and applied mitomycin C in cancer treatment for its antitumor properties. Mitomycin has become a popular chemotherapeutic...
  7. Top 10 Antibiotic Resistant Infections

    Top 10 Antibiotic Resistant Infections
    Antibiotic resistant infections arise when bacteria and other microbes develop immunity against the drugs administered against them. Infections involving antibiotic-resistant strains grow stronger over time and become increasingly difficult to treat. According to CDC reports, over 2.8 million antibiotic-resistant infections occur in the US every year and have lead to a large number of fatalities. Bacteria naturally develop immunities over...
  8. Cibacron Blue Applications

    Cibacron Blue Applications
    Cibacron Blue 3GA is a textile dye or ligand frequently used as a medium for affinity chromatography experiments, specifically for the purification of enzymes. The ligand appears as a blue powder under room temperature settings. Scientists and researchers commonly choose the compound for its affordability, ease of immobilization, high resistance against biological and chemical degradation, and high protein-binding capacity of...
  9. In Vitro Mutagenesis for Genetic Research

    In Vitro Mutagenesis for Genetic Research
    Scientists and researchers turn to cloned DNA for various breakthrough studies as they provide multiple genetic copies and DNA segments suitable for wide-scale tests. In vitro mutagenesis is one useful application of cloned DNA, where researchers create a mutation in one segment of the target DNA. The cloned DNA is then transferred into a cell or organism and studied, which provides...
  10. Sources of DNA Contamination in the Laboratory

    Sources of DNA Contamination in the Laboratory
    The polymerase chain reaction (PCR) technique, used to amplify or “copy” small segments of DNA, is highly sensitive - and that’s a good thing. PCR is a widely used and inexpensive technique used in medical diagnostics, forensic analysis of DNA, and genomic research. Unfortunately, this sensitivity leaves PCR vulnerable to nucleic acid contamination: even trace amounts of DNA can be...

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