1. In Vitro Mutagenesis for Genetic Research

    In Vitro Mutagenesis for Genetic Research
    Scientists and researchers turn to cloned DNA for various breakthrough studies as they provide multiple genetic copies and DNA segments suitable for wide-scale tests. In vitro mutagenesis is one useful application of cloned DNA, where researchers create a mutation in one segment of the target DNA. The cloned DNA is then transferred into a cell or organism and studied, which provides...
  2. Pathology Research Using Mitophagy Modulators

    Pathology Research Using Mitophagy Modulators
    Pathology Research Using Mitophagy Modulators When you hear “small things with big impact”, do you immediately think of mitochondria and mitophagy modulators? Probably not! But these little organelles are champions of cell regulation.  Among their functions is regulating the energy of the cell as well as cell death. And just as mitochondria are responsible for cell function, mitophagy is responsible...
  3. Ruthenium: Applications in Medical & Energy Technologies

    Ruthenium: Applications in Medical & Energy Technologies
    Ruthenium: Applications in Medical & Energy Technologies Ruthenium is used as a catalyst, in addition to being one of the rarest metals on the planet. It speeds up chemical processes with precision and aides in electrochemical energy technologies as well as renewable energy conversions. It is mainly found with platinum in small amounts around the world, and for being so...
  4. Single-Use Biosensors for the Detection of Biomarkers

    Single-Use Biosensors for the Detection of Biomarkers
    Understanding Biosensors Biosensors are devices used in identifying a selective range of analytes (specific substances that require detection). The device comprises two elements: a biological component and physicochemical detector (also known as the transducer). Each biosensor functions by converting biological responses into readable electrical signals. This process is achieved by generating signatures proportional to the concentration of the analyte. The...
  5. Bestatin (Ubenimex): Applications in Life Science Research

    Bestatin (Ubenimex): Applications in Life Science Research
    Bestatin, also known as Ubenimex, is a competitive protease inhibitor. It is an inhibitor of aminopeptidase B, leukotriene A4 hydrolase, aminopeptidase N. It is being studied for use in the treatment of acute myelocytic leukemia.
  6. Beta-Lactamase and Microbial Antibiotic Resistance

    Beta-Lactamase and Microbial Antibiotic Resistance
    β-Lactamases continue to be the leading cause of resistance to β-lactam antibiotics among gram-negative bacteria. In recent years there has been an increased incidence and prevalence of extended-spectrum β-lactamases (ESBLs), enzymes that hydrolyze and cause resistance to oxyimino-cephalosporins and aztreonam.
  7. What is Thapsigargin? Frequently Asked Questions

    What is Thapsigargin? Frequently Asked Questions
    Thapsigargin is derived from the plant Thapsia garganica that produces tumor promoters. This effect is a result of emptying the intracellular calcium stores, which leads to a chain of events that causes apoptosis. Mechanism of Action Chemical structure of Thapsigargin Thapsigargin is an inhibitor of sarco endoplasmic reticulum Ca2 ATPase (SERCA). It pumps calcium ions from the cytoplasm into the lumen...
  8. RNase A: Frequently Asked Questions

    RNase A: Frequently Asked Questions
    Introduction to RNase Ribonucleases (RNases) are a large group of hydrolytic enzymes that degrade ribonucleic acid (RNA) molecules. These are nucleases that catalyze the breakdown of RNA into smaller components. They are a superfamily of enzymes which catalyze the degradation of RNA, operating at the levels of transcription and translation. 3D conformation of ribonuclease A enzyme These enzymes are present...
  9. Rapamycin: Most Commonly Asked Questions

    Rapamycin: Most Commonly Asked Questions
    Discovery of Rapamycin Rapamycin is a macrocyclic triene antibiotic that binds to the cytosolic protein FK-binding protein 12 (FKBP12) and inhibits mTOR pathway by directly binding to the mTOR Complex 1 (mTORC1). It is a potent immunosuppressant having a variety of uses both in vitro and in vivo and is used to prevent organ rejection after transplantation. Chemical structure of...
  10. Ponasterone A - Insect Steroid Hormones and Gene Switching

    Ponasterone A - Insect Steroid Hormones and Gene Switching
    Insect steroid hormones, responsible for molting and metamorphosis, are known for their gene switching functionality. Researchers have benefited from using Ponasterone A, an insect steroid hormone, for medical research. From cancer prevention to therapeutic approaches in neurodegenerative diseases, Ponasterone A has played an important role in scientific studies. What is Ponasterone A? Insect steroid hormones also called ecdysteroids, are a...

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