1. Bestatin (Ubenimex): Applications in Life Science Research

    Bestatin (Ubenimex): Applications in Life Science Research
    Bestatin, also known as Ubenimex, is a competitive protease inhibitor. It is an inhibitor of aminopeptidase B, leukotriene A4 hydrolase, aminopeptidase N. It is being studied for use in the treatment of acute myelocytic leukemia.
  2. PMSF Inhibitor: Frequently Asked Questions

    PMSF Inhibitor: Frequently Asked Questions
    About PMSF Inhibitor An important serine protease inhibitor commonly utilized by biochemists and researchers, phenylmethylsulfonyl fluoride (PMSF) is often used to prepare cell lysates, helping to preserve critical samples. Acting as a non-specific inhibitor, PMSF is often used to protect samples against the digestive functions of proteases, such as trypsin, chymotrypsin, and thrombin, as well as other enzymes. It is...
  3. IPTG Triggers the Transcription of the Lac Operon

    IPTG Triggers the Transcription of the Lac Operon
    Isopropyl β-D-1-thiogalactopyranoside, abbreviated IPTG, is a molecular biology reagent. This compound is used as a molecular mimic of allolactose, a lactose metabolite that triggers transcription of the lac operon.
  4. A Guide to Necroptosis Inhibitors

    There is extensive evidence that necrosis plays a prominent role in a wide range of human pathological conditions, such as myocardial infarct, ischemic injury and neurodegeneration. Therefore, development of necrosis inhibitors is of high interest.
  5. Guide to Necrosis Signaling Pathway Inhibitors

    Necrosis is the premature death of cells in living tissue and can be caused by external factors to the cell or tissue, such as infection, toxins, cancer, infarction, poisons, ROS (Reactive Oxygen Species), inflammation or trauma. Necrosis inhibitors can counteract the effects that may normally cause cell death.   Historically, cell death has been subdivided into regulated (apoptosis, AKA programmed...
  6. Chymostatin (Protease Inhibitor) - Frequently Asked Questions

    Microbial product, chymostatin was discovered by H. Umezawaet al.v in 1970 by testing the anti-chymotrypsin activity of culture filtrates. Since the amino acid analysis of different samples gave variable ratios of phenylalanine, leucine, valine and isoleucine, chymostatin was considered to be a mixture of similar peptides with minor differences. Attempts to separate the components were unsuccessful.
  7. How to Use Proteases for Protein Proteolysis

    How to Use Protease/s for Protein Proteolysis Protein Proteolysis refers to the use of hydrochloric acid to destroy peptide bonds between the amino acids that make up a protein. When carried out with proteases (also known as proteinases), which are enzymes, the process is termed proteolysis. Depending on how efficient the enzyme is or what links it breaks, the proteolysis can be limited or unlimited. Proteolysis can begin either from one end of the chain of amino acids that comprise the protein or somewhere in the middle of it. Unlimited proteolysis produces individual amino acids while limited proteolysis produces short chains of polypeptides.
  8. E-64, Cysteine Protease Inhibitor: Frequently Asked Questions

    E-64, Cysteine Protease Inhibitor: Frequently Asked Questions
    Irreversible, potent and highly selective inhibitor of cysteine proteases. Does not affect cysteine residues in other enzymes. Acts by forming a thioether bond with thiol of the active cysteine. E-64 will not inhibit serine proteases (except trypsin) inhibits activation-induced programmed cell death and restores defective immune responses in HIV+ donors. Specific active site titrant.
  9. Phosphatase Inhibitor Cocktails, Ready Made Formulations

    Invasive phosphatases can contaminate research samples and slow or halt research progress, rendering time-consuming and expensive work useless.

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