1. Mitomycin C Applications in Life Sciences

    Mitomycin C Applications in Life Sciences
    Mitomycin C (C15H18N4O5) is a chemical product derived from Streptomyces caespitosus, an actinobacteria species. It appears as a blue-violet crystal or powder at room temperature. The product is soluble in water and rapidly degrades in acidic preparations. Healthcare researchers and scientists have studied and applied mitomycin C in cancer treatment for its antitumor properties. Mitomycin has become a popular chemotherapeutic...
  2. PMSF: Serine Protease Inhibitor Applications

    PMSF: Serine Protease Inhibitor Applications
    Understanding PMSF PMSF (phenylmethylsulfonyl fluoride) is an irreversible serine protease inhibitor used in various research and lab settings. The compound has a white powdery appearance at room temperature, with a melting point between 90-95°C. It functions by inhibiting serine proteases such as trypsin, chymotrypsin, and thrombin, and cysteine proteases like papain. The process involves the deactivation of enzymes that contain...
  3. Hydroxychloroquine: Misconceptions in the Media

    Hydroxychloroquine: Misconceptions in the Media
    Hydroxychloroquine: Misconceptions in the Media It’s hard to miss hearing the word “hydroxychloroquine” being associated with coronavirus in the news right now.  Hydroxychloroquine is being touted as a “game changer” in treating coronavirus by people in the current US administration who are not medical professionals. This drug has a similar structure to a previously established drug called CQ (N4-(7-Chloro-4-quinolinyl)-N1,N1-diethyl-1,4-pentanediamine), which...
  4. Bestatin (Ubenimex): Applications in Life Science Research

    Bestatin (Ubenimex): Applications in Life Science Research
    Bestatin, also known as Ubenimex, is a competitive protease inhibitor. It is an inhibitor of aminopeptidase B, leukotriene A4 hydrolase, aminopeptidase N. It is being studied for use in the treatment of acute myelocytic leukemia.
  5. PMSF Inhibitor: Frequently Asked Questions

    PMSF Inhibitor: Frequently Asked Questions
    About PMSF Inhibitor An important serine protease inhibitor commonly utilized by biochemists and researchers, phenylmethylsulfonyl fluoride (PMSF) is often used to prepare cell lysates, helping to preserve critical samples. Acting as a non-specific inhibitor, PMSF is often used to protect samples against the digestive functions of proteases, such as trypsin, chymotrypsin, and thrombin, as well as other enzymes. It is...
  6. IPTG Triggers the Transcription of the Lac Operon

    IPTG Triggers the Transcription of the Lac Operon
    Isopropyl β-D-1-thiogalactopyranoside, abbreviated IPTG, is a molecular biology reagent. This compound is used as a molecular mimic of allolactose, a lactose metabolite that triggers transcription of the lac operon.
  7. Beta Lactamase Inhibitors in Anti-Seizure Research

    Beta Lactamase Inhibitors in Anti-Seizure Research
    Beta-lactam antibiotics contain a cyclic amide ring of which mimics the structure of the terminal amino acid residues comprising the peptidoglycan matrix. It is this structure that the enzyme Beta-Lactamase acts upon as a method of antibiotic defense, hydrolyzing the ring and compromising the structure as a result. Structure and function are intrinsically related; without proper structure, the function is...
  8. Top 7 FAQs About Beta-Lactamase

    Top 7 FAQs About Beta-Lactamase
    As a core structure in many antibiotics, the beta-lactam ring is a cyclic amide. Beta-lactam antibiotics almost universally inhibit bacterial cell wall synthesis and thus induce the destruction of bacterial cells. Bacteria have evolved an enzyme that combats this antibiotic and increases resistance to death induced by antibiotic means: the beta-lactamase enzyme. Beta-lactamase enzymes can be used in a multitude...
  9. Fighting HIV with Protease Inhibitors

    Fighting HIV with Protease Inhibitors
    HIV relies on the host cell it injects itself into to continue the cycle. By implicating road blocks in this process through protease inhibitors, there is a possibility of halting the replication and spread of the HIV virus. 7 Steps of the HIV Life Cycle: The first step of the HIV cycle is binding, when the virus first attaches to...
  10. 20 FACTS ABOUT PROTEASOMES & PROTEASOME INHIBITORS!

    1. Proteasome inhibitors are drugs that block the action of proteasomes, cellular complexes that break down proteins, like the p53 protein. Proteasome inhibitors are being studied in the treatment of cancer, especially multiple myeloma.

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