1. Top 10 FAQs About Inhibitor CHIR99021

    Top 10 FAQs About Inhibitor CHIR99021
    Any questions about Inhibitor CHIR99021? See all about it in the post below. What is inhibitor CHIR99021? CHIR99021 (CT99021), is also known as 6-amino]ethyl]amino]-3-pyridinecarbonitrile and CT99021. It is the most potent and selective inhibitor of GSK3. CHIR99021 is an aminopyrimidine derivative. It inhibits GSK3 β and GSK3 α. It also functions as a WNT activator. It is the most selective...
  2. The CHIR99021 GSK-3 Inhibitor Mechanism

    The CHIR99021 GSK-3 Inhibitor Mechanism
    The CHIR99021 GSK-3 Inhibitor is both potent and selective. Small membrane-permeable molecules are widely utilized for maintenance and differentiation of embryonic stem cells (ES) of different species. Glycogen synthase kinase 3 (GSK3) activates the Wnt/beta-catenin pathway when targeted for inhibition. GSK3 is a conserved signaling molecule with essential roles in diverse biological processes. GSK3 activity has been linked to a...
  3. Thapsigargin Applications: Glioblastoma Multiforme Studies

    Thapsigargin Applications: Glioblastoma Multiforme Studies
    Glioblastoma multiforme is the most aggressive and malignant form of gliomas, a group of tumors arising from glial cells of the brain. Glioblastomas are very difficult to treat due to the diffused nature of the tumor itself. The tumor cells have a distinct invasive feature of spreading and diffusing into different parts of the brain. This characteristic feature of these...
  4. A Promising Cancer Therapy: Thapsigargin's Anti-Cancer Roles

    A Promising Cancer Therapy: Thapsigargin's Anti-Cancer Roles
    Thapsia Garganica is a common Mediterranean weed  highly toxic to sheep and cattle, thus earning the nickname death carrot. Thapsigargin is a natural cytotoxin derived from the plant Thapsia Graganica. Oncologists Samuel Denmeade at Johns Hopkins University, Baltimore and his team has extensively researched methods to harness thapsigargin's toxicity, and develop, as result, a potential and novel anti-cancer therapeutic and...
  5. Society of Neuroscience Holds Conference in San Diego

    Society of Neuroscience Holds Conference in San Diego
    Innovative Discoveries: Science Presented at Neuroscience 2016 Neuroscience 2016 took place November 12-16 at the San Diego Convention Center. The Society for Neuroscience's 46th annual meeting is the premier venue for neuroscientists to meet, present emerging science, learn from experts, collaborate with peers, explore new tools and technologies, and advance careers. There were more than 30,000 colleagues from more than...
  6. Beta Lactamase Inhibitors in Research: Anti-Seizure

    Beta Lactamase Inhibitors in Research: Anti-Seizure Beta-lactam antibiotics contain a cyclic amide ring of which mimics the structure of the terminal amino acid residues comprising the peptidoglycan matrix. It is this structure that the enzyme beta lactamase acts upon as a method of antibiotic defense, hydrolyzing the ring and compromising the structure as a result. Structure and function are intrinsically...
  7. Oncologic Neurosurgery: My Awake Brain Surgery

    Oncologic Neurosurgery: My Awake Brain Surgery
    Photograph: CEO Chip Lindgren and Dr. Linda M. Liau (His Neurosurgeon.) In June 2001, our CEO Chip Lindgren suddenly found out he was diagnosed with oligodendroglioma brain cancer. He was able to buy time with world leading surgeons that have over watched breakthroughs in cancer immunotherapy (immuno-oncology) and viral oncology research. Chip was one of the first to receive awake...
  8. Alcohol, Cancer, and Dying: Research 2016

    Alcohol, Cancer, and Dying: Research 2016
    2016 is a big year for cancer research! Research from across the world has been reporting a mix of good and bad, with the scariest showing a list of alcohol-related cancer diseases and the best news of all showing a trick to cheat death. Do you drink alcohol? Did you know that alcohol can cause cancer of the oropharynx, larynx...
  9. AG Presents: Meet Milos Lazic of Jecure Therapeutics [Ep. 1]

    AG Presents: Meet Milos Lazic of Jecure Therapeutics [Ep. 1]
    AG Presents is an interview series of scientists in the Life Sciences industry that share insights to what research life is like as a start-up, in a university, or at an institute and how they got there. Here we would love to introduce Milos Lazic of Jecure Therapeutics in San Diego, California, USA. Q: Could you tell us about your...
  10. Top 7 FAQs About Beta-Lactamase

    Top 7 FAQs About Beta-Lactamase
    Top 7 FAQs About Beta-Lactamase As a core structure in many antibiotics, the beta-lactam ring is a cyclic amide. Beta-lactam antibiotics almost universally inhibit bacterial cell wall synthesis and thus induce the destruction of bacterial cells. Bacteria have evolved an enzyme that combats this antibiotic and increases resistance to death induced by antibiotic means: the beta-lactamase enzyme. Beta-lactamase enzymes can...
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