1. PMSF: Serine Protease Inhibitor Applications

    PMSF: Serine Protease Inhibitor Applications
    Understanding PMSF PMSF (phenylmethylsulfonyl fluoride) is an irreversible serine protease inhibitor used in various research and lab settings. The compound has a white powdery appearance at room temperature, with a melting point between 90-95°C. It functions by inhibiting serine proteases such as trypsin, chymotrypsin, and thrombin, and cysteine proteases like papain. The process involves the deactivation of enzymes that contain...
  2. Nanopore Electrochemistry: Single-Molecule Sensors

    Nanopore Electrochemistry: Single-Molecule Sensors
    A trend in modern scientific research over the past decade is using smaller & smaller methods of studying targets, like molecules. Independent, smaller devices, and less expensive methods allow more access for researchers across the board, regardless of their space and budget. One such analytical method is the creation of artificial nanopore sensors for research using nanopore electrochemistry. Capturing reactions...
  3. Using Bicyclomycin to Treat Drug-Resistant Bacterial Infections

    Using Bicyclomycin to Treat Drug-Resistant Bacterial Infections
    Stating that antibiotics, first discovered in 1928 and commercially used by the 1940s, brought an unprecedented change to the world is not an overstatement. For decades now we have routinely cured illnesses and infections that were previously life-threatening. In recent years, however, bacterial infections have increasingly grown resistant to antibiotics. According to the CDC, approximately 2.8 million people each year...
  4. The SUnSET Assay: Powerful Proteomics

    The SUnSET Assay: Powerful Proteomics
    The SUnSET Assay: Powerful Proteomics Exciting advances in the study of protein synthesis and related health conditions are on the horizon! Research scientists have developed an improved process to quantify and understand the processes of protein synthesis in singular eukaryotic cells/cell populations. It’s called the surface sensing of translation, or SUnSET assay. It is a nonradioactive fluorescence-activated assay, which means...
  5. Amphotericin B for Viral Disease Research

    Amphotericin B for Viral Disease Research
    Amphotericin B for Viral Disease Research Amphotericin B is an antibiotic that has been used for over fifty years as an aggressive and effective antifungal treatment.  It battles serious fungal infections like cryptococcal meningitis with ease.  Often called by its brand name, Fungizone, this antibiotic is effective in saving lives and has been relied upon for decades because pathogens have...
  6. Poly(A) for Vital COVID-19 Research

    Poly(A) for Vital COVID-19 Research
    Poly(A) for Vital COVID-19 Research Nothing is more at the forefront in scientific news right now than the Coronavirus pandemic. Testing for the COVID-19 vaccine is at the top of the list for research scientists and there is dramatically increased demand for chemical materials to observe and measure coronavirus protein synthesis. Polyadenylic acid, or poly(A), is one of these critical...
  7. Pathology Research Using Mitophagy Modulators

    Pathology Research Using Mitophagy Modulators
    Pathology Research Using Mitophagy Modulators When you hear “small things with big impact”, do you immediately think of mitochondria and mitophagy modulators? Probably not! But these little organelles are champions of cell regulation.  Among their functions is regulating the energy of the cell as well as cell death. And just as mitochondria are responsible for cell function, mitophagy is responsible...
  8. Hydroxychloroquine: Misconceptions in the Media

    Hydroxychloroquine: Misconceptions in the Media
    Hydroxychloroquine: Misconceptions in the Media It’s hard to miss hearing the word “hydroxychloroquine” being associated with coronavirus in the news right now.  Hydroxychloroquine is being touted as a “game changer” in treating coronavirus by people in the current US administration who are not medical professionals. This drug has a similar structure to a previously established drug called CQ (N4-(7-Chloro-4-quinolinyl)-N1,N1-diethyl-1,4-pentanediamine), which...
  9. Guanidine Thiocyanate in RNA Lysis Buffers and COVID-19 Research

    Guanidine Thiocyanate in RNA Lysis Buffers and COVID-19 Research
    With COVID-19 ever present on our minds, viral research is being focused on now more than anything else. We at AG Scientific have remained open to meet the needs of the research community and are stocking chemical agents such as guanidine thiocyanate.  Read on to learn more about this chemical and how it can aid your lab research. What Is...
  10. Tunicamycin: ER Stress Inducer

    Tunicamycin: ER Stress Inducer
    Tunicamycin: ER Stress Inducer When we hear the terms cell death and endoplasmic reticulum (ER) stress, what first comes to mind?  3D illustration of protein folding Stress? Death? Two concepts that don’t exactly inspire positive thoughts.  However, in the case of the antibiotic compound tunicamycin, cell death and ER stress are the objectives.  What is Tunicamycin? Tunicamycin is an antibiotic...

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