1. Puromycin FAQs

    Puromycin is an antibiotic researchers can use when working with cell cultures when they need a selective agent, a compound that will kill all cells without resistance genes, leaving only specific targets behind. This antibiotic is available through laboratory suppliers and is suitable for research purposes only.
  2. 7 G-418 features that will surprise you!

    G-418 (Geneticin) is an aminoglycoside antibiotic similar in structure to gentamicin B1. It is produced by Micromonospora rhodorangea. G418 blocks polypeptide synthesis by inhibiting the elongation step in both prokaryotic and eukaryotic cells.
  3. Cefsulodin used in treatment of fungal meningitis

    1. Cefsulodin in the treatment of Pseudomonas meningitis Three patients with meningitis due to Pseudomonas aeruginosa (in one patient following a neurosurgical procedure and in two patients following severe head trauma with multiple skull bone fractures and liquorrhea) were treated with cefsulodin in combination with other antibiotics (aminoglycosides/acylureido penicillins). All of the patients were cured. Two patients received intraventricular administrations of aminoglycosides in addition to systemically applied antibiotics. After recurrence of pseudomonas meningitis in one patient in spite of the intraventricular application of an aminoglycoside, definite cure could only be obtained by additional intraventricular application of cefsulodin. The third patient was cured by systemic administration of cefsulodin and amikacin. The value of cefsulodin is discussed with reference to obtainable ventricular and lumbar CSF concentrations.
  4. 48 FAQS, Protocols & review articles for the PLA2 inhibitor, MAFP.

    Description: Methoxy arachidonyl fluorophosphonate, commonly referred as MAFP, is an irreversible active site-directed enzyme inhibitor that inhibits nearly all serine hydrolases and serine proteases[1]. It inhibits phospholipase A2 (PLA2) and fatty acid amide hydrolase with special potency, displaying IC50 values in the low-nanomolar range.
  5. VEGF-Mimetic Nanofibers for Ischemic Tissue Repair

    Researchers report on a new approach to treating ischemia based on the administration of nanofilaments carrying VEGF-mimetic peptides. The cell-free technology comprises self-assembling peptide amphiphile (PA) nanostructures that display high densities of the VEGF-mimetic peptides on their surface.
  6. DTT (Dithiothreitol): Frequently Asked Questions

    For the last 18 years, AG Scientific has been a leading supplier of DTT, dithiothreitol, historically known as Cleland’s Reagent. We offer a range of catalog sizes, as well as, multi-kilogram quantities for bulk applications. Additionally, we provide a full service of bottling, sterile formulations, custom packaging, as well as, comprehensive private labeling capabilities.
  7. 5 VITAL ACTINONIN APPLICATIONS

    Actinonin is a naturally occurring antibacterial agent that has demonstrated anti-tumor activity. The natural product peptidimetic actinonin demonstrates antiproliferative, antiangiogenic, and antimetastatic properties against many human cancers, including leukemia and lymphoma, as well as against lung and prostate tumors, both in vitro and in vivo.
  8. AEBSF AS A KEY BIOMARKER

    AEBSF or 4-(2-Aminoethyl) benzenesulfonyl fluoride hydrochloride is a water-soluble, irreversible serine protease inhibitor with a molecular weight of 239.5 Da. It inhibits proteases like chymotrypsin, kallikrein, plasmin, thrombin, and trypsin. The specificity is similar to the inhibitor PMSF, nevertheless, AEBSF is more stable at low pH values. Typical usage is 0.1 - 1.0 mM. AEBSF is used as a protease...
  9. 26 FAQS on Octyl-glucoside, (OG) biodetergent

    A non-ionic detergent intended for solubilizing membrane-bound proteins in theirnative state and for the preparation of lipid vesicles. Its well defined chemical structure, small uniform micelles and high water solubility make it superior to most other non-ionic detergent for membrane solubilization.
  10. 4 FACTS YOU SHOULD KNOW ABOUT ASCOMYCIN

    Ascomycin, also called Immunomycin, FR-900520, FK520, is an ethyl analog of tacrolimus (FK506) with strong immunosuppressant properties. Ascomycin acts by binding to immunophilins, especially macrophilin-12. It appears that Ascomycin inhibits the production of Th1 (interferon- and IL-2) and Th2 (IL-4 and IL-10) cytokines. Additionally, ascomycin preferentially inhibits the activation of mast cells, an important cellular component of the atopic response. Ascomycin produces a more selective immunomodulatory effect in that it inhibits the elicitation phase of allergic contact dermatitis but does not impair the primary immune response when administered systemically.

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