1. Fiber Linked To Reduced Risk Of Breast Cancer

    A large new epidemiological study appears to provide further evidence that regular intake of fiber from fruits, vegetables and whole grains is associated with a reduced risk of developing breast cancer in women.
  2. SB-431542, specific Inhibitor of receptor-like kinase (ALK)5.

    TGF-β superfamily members signal through a receptor complex comprising a type II and type I receptor, both serine/threonine kinases. Here, we characterize a small molecule inhibitor (SB-431542) that was identified as an inhibitor of activin receptor-like kinase (ALK)5 (the TGF-β type I receptor).
  3. Sulfobetaines, Zwitterionic Biodetergents in Diagnostics

    Improving reagent performance in immunoassays both to enhance assay sensitivity and to minimize interference are ongoing challenges in clinical diagnostics. We describe herein the syntheses of a new class of hydrophilic reagents containing sulfobetaines zwitterions and their applications.
  4. A Guide to Necroptosis Inhibitors

    There is extensive evidence that necrosis plays a prominent role in a wide range of human pathological conditions, such as myocardial infarct, ischemic injury and neurodegeneration. Therefore, development of necrosis inhibitors is of high interest.
  5. A-83-01 Considered A Fighting Component in Cancer Treatment

    In a study on how the ALK-5 inhibitor A-83-01 inhibits Smad signaling and epithelial-to-mesenchymal transition by transforming growth factor-β, A-83-01 was synthesized and characterized a small molecule inhibitor. It is structurally similar to previously reported ALK-5 inhibitors developed by Sawyer et al. (2003) and blocks signaling of type I serine/threonine kinase receptors for cytokines of the TGF-β superfamily (known as activin receptor-like kinases; ALKs).
  6. ENZASTAURIN: FIGHTING MALIGNANT CANCERS

    Enzastaurin is a synthetic bisindolylmaleimide with potential antineoplastic activity. Binding to the ATP-binding site, enzastaurin selectively inhibits protein kinase C beta, an enzyme involved in the induction of vascular endothelial growth factor (VEGF)-stimulated neo-angiogenesis.
  7. Anti-Angiogenic Foods: Fight Cancer with Dietary Changes

    Anti-Angiogenic Foods: Fight Cancer with Dietary Changes
    Eating to defeat cancer can simply be done by adding a few cancer fighting angio foods to your meals each day. Why not choose foods that can help reduce your risk of disease?
  8. Sonic Hedgehog Signaling Pathway

    Activation of the hedgehog pathway has been implicated in the development of cancers in various organs, including brain, lung, mammary gland, prostate and skin. Basal cell carcinoma, the most common form of cancerous malignancy, has the closest association with hedgehog signaling.
  9. Withaferin A (WA) FAQS

    Withaferin A (WA) is derived from the medical plant Withania somnifera (commonly known as ashwagandha or Indian winter cherry), which has been safely used for centuries in Indian Ayurvedic medicine for treatment of different ailments. Suppresion of angiogenisis, alteration of cytoskeletal architecture, and inhibition of proteasomal activity by WA has also been documented.
  10. WY-14,643 - Pirinixic acid

    Pirinixic acid (Wy-14,643) is an agonistWY-14,643 - Pirinixic Acid of the peroxisome proliferator-activated receptor (PPAR) subtype α exhibiting beneficial effects in various inflammation-related processes in a slow, long-termed fashion.

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