1. Exploring the uses of pepstatin A

    Pepstatin A is of microbial origin and is an N-acyl-pentapeptide, more accurately: isovaleryl-L-valyl-L-valyl-statyl-L-alanyl-statine. Pepstatin A was found to be a potent competitive inhibitor of most aspartic proteases but a weak inhibitor of renin.
  2. Thaxtomin A affects CESA-complex density, expression of cell wall genes, cell wall composition, and causes ectopic lignification in Arabidopsis thaliana seedlings

    Thaxtomin A, a phytotoxin produced by Streptomyces eubacteria, is suspected to act as a natural cellulose synthesis inhibitor. This view is confirmed by the results obtained from new chemical, molecular, and microscopic analyses of Arabidopsis thaliana seedlings treated with thaxtomin A.
  3. Chemotin and HIF-1

    Hypoxia-inducible factor-1 (HIF-1) is a transcriptional complex that is activated in response to hypoxia and growth factors. HIF-1 plays a central role in tumor progression, invasion, and metastasis.
  4. Cycloheximide-induced T-cell Death Is Mediated by a Fas-associated Death Domain-dependent Mechanism

    Cycloheximide (CHX) can contribute to apoptotic processes, either in conjunction with another agent (e.g. tumor necrosis factor-α) or on its own. The apoptotic process is now known to involve the well orchestrated interactions of cell death receptors, death receptor adaptors, caspases, and Bcl-2 family members.
  5. How mitotic inhibitors work in Chemotherapy.

    The Salk Institute says it appears to have serendipitously solved a long standing mystery about how a key class of chemotherapy drugs work, which could lead to better ways of fighting a wide variety of cancers, including tumors of the breast, ovaries, colon, lung and prostate.
  6. Want to see your genome on a smartphone?

    Portable Genomics, a new La Jolla startup, is seeking investors to help underwrite its plan to commercially develop software that can display a person's genetic information on such devices as smartphones and electronic tablets.
  7. Innovator Tracks Everything His Body Does

    Larry Smarr stops a visitor and says, “Before you go, let me show you my stool sample.” The UC San Diego physicist-futurist reaches into his kitchen refrigerator, past the milk, and pulls out a small white box. He marvels over its contents. “The bacteria in here contains more info than you’d find on a computer chip,” Smarr says. “It’s a window into your health. Within 10 years, people won’t dream of going to a doctor without first getting a sample like this.” Feeling squeamish? Smarr can have that effect on people. Virtually nothing is out-of-bounds these days when he promotes the “Quantified Self,” an emerging movement in which people use biosensors and other gadgets to closely monitor their bodies in the name of wellness.
  8. Resveratrol in grapes contains anti-cancer properties

    The naturally occurring dietary compound, trans-resveratrol (trans-3,4',5-trihydroxystilbene), a natural phytoalexin present in grape skins, red wines, and grape juices, is sold over the counter in the United States as a nutritional supplement.
  9. Quinomycin A, HIF-1 Inhibitor

    Quinomycin A, also referred to as Echinomycin, is a peptide antibiotic which binds strongly to double-helical DNA up to a limit of approximately one molecule per five base-pairs. There is no detectable interaction with rRNA and only extremely feeble non-specific interaction with poly(rA) .poly(rU).
  10. Robotnikinin blocks Hedgehog signaling in cancer, development

    Researchers have achieved a feat drug developers had thought difficult, if not impossible, discovering a compound that blocks the functioning of a key developmental protein by binding to an “undruggable” target — an advance that may provide a new avenue to fight skin, pancreatic, prostate, and other cancers.

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