1. Daptomycin: Frequently Asked Questions - Answered!

    Daptomycin: Frequently Asked Questions - Answered!
    For the last 15 years, A.G. Scientific has been a leading supplier of Daptomycin. We offer a range of catalog sizes, as well as, multi-kilogram quantities for bulk applications. Additionally, we provide a full service of bottling, sterile formulations, custom packaging, as well as, comprehensive private labeling capabilities.
  2. IPTG: Frequently Asked Questions and Protocols

    IPTG: Frequently Asked Questions and Protocols
    IPTG is a molecular biology reagent utilized in cloning experiments. This compound is used as a molecular mimic of allolactose, a lactose metabolite that triggers transcription of the lacoperon. Unlike allolactose, the IPTG sulfur (S) atom creates a chemical bond which is non-hydrolyzable by the cell, preventing the cell from "eating up" or degrading the inductant; therefore the IPTG concentration remains constant.
  3. PMSF Inhibitor: Frequently Asked Questions

    PMSF Inhibitor: Frequently Asked Questions
    About PMSF Inhibitor An important serine protease inhibitor commonly utilized by biochemists and researchers, phenylmethylsulfonyl fluoride (PMSF) is often used to prepare cell lysates, helping to preserve critical samples. Acting as a non-specific inhibitor, PMSF is often used to protect samples against the digestive functions of proteases, such as trypsin, chymotrypsin, and thrombin, as well as other enzymes. It is...
  4. G418 Sulfate (Geneticin): Protocols and FAQs

    G418 Sulfate (Geneticin): Protocols and FAQs
    or the last 18 years, AG Scientific has been a leading manufacturer, retail supplier and wholesaler of g-418, Geneticin®. Our success with a combination of fermentation & synthesis that has allowed us to build a catalog of over 180 antibiotics and a customer base of researchers, catalog biochemical distributors and cell media manufacturers worldwide.
  5. What is Thapsigargin? Frequently Asked Questions

    What is Thapsigargin? Frequently Asked Questions
    Thapsigargin is derived from the plant Thapsia garganica that produces tumor promoters. This effect is a result of emptying the intracellular calcium stores, which leads to a chain of events that causes apoptosis. Mechanism of Action Chemical structure of Thapsigargin Thapsigargin is an inhibitor of sarco endoplasmic reticulum Ca2 ATPase (SERCA). It pumps calcium ions from the cytoplasm into the lumen...
  6. CHAPS Detergent: Protocols and Frequently Asked Questions

    CHAPS Detergent: Protocols and Frequently Asked Questions
    A nondenaturing zwitterionic detergent for solubilizing membrane proteins and breaking protein-protein interactions. Combines the useful properties of both the sulfobetaine-type and the bile salt detergents. Commonly used for protein solubilization in isoelectric focusing and two-dimensional electrophoresis especially for non-denaturing (without urea) isoelectric focusing.
  7. RNase A: Frequently Asked Questions

    RNase A: Frequently Asked Questions
    Introduction to RNase Ribonucleases (RNases) are a large group of hydrolytic enzymes that degrade ribonucleic acid (RNA) molecules. These are nucleases that catalyze the breakdown of RNA into smaller components. They are a superfamily of enzymes which catalyze the degradation of RNA, operating at the levels of transcription and translation. 3D conformation of ribonuclease A enzyme These enzymes are present...
  8. Laboratory and Medicinal Uses for SDS Detergent

    Laboratory and Medicinal Uses for SDS Detergent
    Sodium dodecyl sulfate (SDS or NaDS), sodiumlaurilsulfate or sodium laurel sulfate (SLS) is an organic compound with the formula CH3(CH2)11OSO3Na. It is an anionic surfactant used in many cleaning and hygiene products.
  9. Dithiothreitol (DTT) Applications You Must Know

    Dithiothreitol (DTT) Applications You Must Know
    Dithiothreitol (DTT), also known as Cleland's reagent, is a small-molecule redox reagent. Its oxidized form is a disulfide-bonded 6-membered ring. DTT has an epimeric ('sister') compound, dithioerythritol (DTE).
  10. TCEP HCl vs DTT: Preferred Reducing Reagents

    TCEP HCl vs DTT: Preferred Reducing Reagents
    TCEP. HCl has the advantages of being odorless, a more powerful reducing agent, an irreversible reducing agent, more hydrophilic, and more resistant to oxidation in air. Near complete reduction of disulfide bonds. DTT is a protective agent for reducing –S-S TO SH groups. Used as a strong reducing agent for proteins and enzymes.

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