• Anthracyclines: Anti-Cancer Compounds 2018-12-03 09:00:57 Anthracyclines are anticancer compounds that were originally derived from Streptomyces and their anti-tumor activitieswere established in the 1960s. Anthracyclines are red aromatic polyketides and occur in variety of forms due to the structural differences in the aglycone and the different sugar res Beaker and pipette
  • The Ultimate Guide to Beta Lactamase 2018-11-20 11:30:59 Beta Lactamase Mechanism Beta lactam antibiotics, like cephams and penicillin derivatives, have a four-member cyclic amide ring that inhibits the peptidoglycan layer synthesis in bacteria. A woven complex of sugar and protein pieces, these first-class bactericidal drugs destroy the integrity of
  • SMER28- Enhancer of Autophagy 2018-06-13 11:07:20 SMER28 is a small-molecule enhancer (SMER) of autophagy that increases autophagosome synthesis and enhances clearance of aggregate-prone substrates, including those relevant to Huntington’s, Parkinson’s, and Alzheimer’s diseases.   It is a positive regulator of autophagy in a
  • Bafilomycin as a Cancer Treatment 2017-07-05 08:48:17 Bafilomycins are a family of toxic macrolide antibiotics isolated from Streptomyces species. AG Scientific offers several high-quality bafilomycin products. Bafilomycins at AG Scientific Product Number Product Name B-1183 Bafilomycin A1 B-1185 Bafilomycin B1 B-1245 Bafilomycin B2 B-2535 Bafilomycin Microscopy
  • 18 Facts about Rapamycin 2017-03-14 11:56:06 Discovery of Rapamycin Rapamycin is a macrocyclic triene antibiotic that binds to the cytosolic protein FK-binding protein 12 (FKBP12) and inhibits mTOR pathway by directly binding to the mTOR Complex1 (mTORC1). It is a potent immunosuppressant having  a variety of uses both in vitro and
  • CHIR 99021 GSK3 Inhibitor’s Role in Stem Cell Research 2017-02-09 11:21:43 Stem cell therapies are the leading and most sensational topic in the world of scientific research. The excitement is due to the huge potential these cells have in curing human diseases. What are stem cells? They are undifferentiated cells in human body that are capable of differentiating into speci
  • A Promising Cancer Therapy: Thapsigargin’s Anti-Cancer Roles 2016-12-06 16:00:21 Thapsia Garganica is a common Mediterranean weed  highly toxic to sheep and cattle, thus earning the nickname “death carrot”. Thapsigargin is a natural cytotoxin derived from the plant Thapsia Graganica. Oncologists Samuel Denmeade at Johns Hopkins Un
  • What is Thapsigargin: Thapsigargin FAQ 2016-12-02 17:51:00 Thapsigargin is a naturally occurring tumor promoter derived from the plant Thapsia garganica. This effect is a result of emptying the intracellular calcium stores, which leads to a chain of events that causes apoptosis. What is thapsigargin? Thapsigargin is a naturally occurring sesquit
  • Paullones, Cancer and Alzheimer Prevention 2015-07-31 08:47:44 In recent studies, Paullones, a class of benzazepinones, have proven to be potent inhibitors of primarily, two protein kinase families: Cyclin Dependent Kinases as well as the Glycogen Synthase Kinase family. Cyclin dependent Kinase, also known as the CDK family is critical for the regulation of spe
  • Gene Repair Mechanism May Hold Key to New Cancer Treatment 2015-04-05 13:25:15 Case Western Reserve researchers have uncovered a new potential cancer therapy that reveals a 2-pronged approach of worsening and then, ultimately, conquering cancer cells. Their complex formulation of genetic and bio-chemical reagents allowed this team of researchers to discover a method of boostin