Neurological disorders are diseases that affect the brain, central and the autonomic nervous system. According to the University Of California San Francisco, there are more than 600 neurological disorders. Of the many neurological disorders, the most common neurodegenerative diseases among US population is Alzheimer's and Multiple sclerosis. The Multiple Sclerosis Foundation estimates that more than 400,000 people in the United States have Multiple Sclerosis, and about 5.5 million Americans live with Alzheimer's dementia. The pathogenesis of these neurodegenerative diseases has been attributed to inflammatory responses in the brain.
Neurological disorders are diseases that affect the brain, central and the autonomic nervous system. According to the University Of California San Francisco, there are more than 600 neurological disorders. Of the many neurological disorders, the most common neurodegenerative diseases among US population is Alzheimer's and Multiple sclerosis. The Multiple Sclerosis Foundation estimates that more than 400,000 people in the United States have Multiple Sclerosis, and about 5.5 million Americans live with Alzheimer's dementia. The pathogenesis of these neurodegenerative diseases has been attributed to inflammatory responses in the brain. The process of the inflammatory response is the release of Pro-inflammatory cytokines, increased expression of endothelial adhesion and chemotactic factors and activation of brain immune effector cells. The brain immune cells, Microglia and Astrocytes are activated by a variety of stimuli. They produce inflammatory cytokines and chemokines that accelerate disease progression. The inflammatory chemokine of interest is Glial cells derived CCL2/MCP-1. It causes initiation and progression of inflammatory responses by promoting recruitment and migration of inflammatory cells. Hence interventions aimed at supporting the activity of CCL2/MCP-1 is the therapeutic strategy for the treatment of neurodegenerative diseases such as Multiple Sclerosis and Alzheimer's disease. Peroxisome proliferator-activated receptors (PPARs) are ligand activated transcription factors. PPARs have been reported to be highly expressed in adipocytes, demonstrated to have important roles in adipocyte differentiation, lipid biosynthesis and glucose homeostasis. A subtype of PPAR, PPAR-γ has been reported to have anti-inflammatory effect on pro-inflammatory molecules. According to several studies PPAR-γactivators have shown promising beneficial effects on animal models of neurodegenerative diseases such as Multiple Sclerosis, Alzheimer's disease, Brain Ischemia.