A23187: A Carboxylic Acid Antibiotic Which Simultaneously Uncouples Oxidative Phosphorylation and Inhibits ATPaseOVERVIEW A23187 is a carboxylic acid antibiotic which simultaneously uncouples oxidative phosphorylation and inhibits ATPase of rat liver mitochondria incubated in a magnesium-free medium. The antibiotic acts as a freely mobile carrier to transport calcium and magnesium, but not potassium, from an aqueous medium buffered at pH 7.4 into a bulk organic phase. A23187 causes a progressive release of endogenous...
The ionophores were first recognized as being a separate class with the publication of the structure for monensin in 1967. Several members of the group have found commercial application as anticoccidials in poultry farming and as growth promoters for cattle, pigs and chickens.