Cycloheximide (Actidione) is an antibiotic which inhibits eukaryotic protein synthesis. Although many yeasts including Saccharomyces cerevisiae are sensitive to cycloheximide, some yeast strains are resistant to this drug.
- It has been shown that cycloheximide (CHM), a well-known protein synthesis inhibitor, reduces Cytotoxicity induced by 1-B-D-arabinofuranosylcytosine, nitrogen mustard, or X-irradiation in normal cells, such as small intestine or bone marrow cells.
- Cycloheximide (CHX) can contribute to apoptotic processes, either in conjunction with another agent (e.g. tumor necrosis factor-Î±) or on its own. The apoptotic process is now known to involve the well orchestrated interactions of cell death receptors, death receptor adaptors, caspases, and Bcl-2 family members.