1. How Alzheimers Causes Dementia

    How Alzheimers Causes Dementia
    Dementia, one of the symptoms of Alzheimers, stems from the neurofibrillary tangles of which form during the development of the disease. The neurofibrillary tangles consist of tau proteins, abnormal clumps within the neurons, and amyloid beta plaques, which form outside the cell and are often accompanied with neuronal death. Both affect neurons that are involved in memory formation, desecrating these...
  2. THC Destroys Amyloid Beta in Alzheimer's (2016 Research)

    THC Destroys Amyloid Beta in Alzheimer's (2016 Research)
    Alzheimer's disease, a brain disorder that causes memory loss and dementia, is one of the leading causes of death and affects more than five million Americans according to the National Institute of Health. With its incidence being projected to triple during the next 50 years, Alzheimer's disease is an increasing problem with the elderly population. Amyloid Beta: What is it...
  3. Breaking News (2016) - HIV Drug May Treat Alzheimer's Disease

    Breaking News (2016) - HIV Drug May Treat Alzheimer's Disease
    Scientists at Case Western University, under the support in part by the Public Health Service Grant, was able to map the allosteric site in Cholesterol Hydroxylase CYP46A1 for efavirenz, a drug used to treat HIV infections, that stimulates enzyme activity. What they Found CYP46A1 is an enzyme responsible for 80 percent of the cholesterol breakdown in the human brain. Efavirenz...
  4. Piperlonguminine: Potential Treatment For Alzheimer's Disease

    Piperlonguminine is a potential novel therapeutic agent for Alzheimer's disease.  Extracellular deposits of Aβ in senile plaques of the cerebral cortex are known to be hallmarks of Alzheimer's disease. Recent studies show that a mix of piperlonguminine and dihydropiperlonguminine significantly inhibit the expression of Amyloid Precursor Protein (APP). The decreased production of the peptide Amyloid β (Aβ) in SK-N-SH cells...

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