Bafilomycins are a family of toxic macrolide antibiotics isolated from Streptomyces species. AG Scientific offers several high-quality bafilomycin products. Bafilomycins at AG Scientific Product Number Product Name B-1183 Bafilomycin A1 B-1185 Bafilomycin B1 B-1245 Bafilomycin B2 B-2535 Bafilomycin C1 B-2537 Bafilomycin D Bafilomycins in Cancer Research The most commonly used bafilomycin is bafilomycin A1 (Baf-A1). Baf-A1 is an autophagy inhibitor...
- Ansamycins is a family of secondary metabolites that show antimicrobial activity against many gram-positive and some gram-negative bacteria and includes various compounds, among which: streptovaricins and rifamycins. In addition, these compounds demonstrate antiviral activity towards bacteriophages and poxviruses.
- Enzastaurin is a synthetic bisindolylmaleimide with potential antineoplastic activity. Binding to the ATP-binding site, enzastaurin selectively inhibits protein kinase C beta, an enzyme involved in the induction of vascular endothelial growth factor (VEGF)-stimulated neo-angiogenesis.
- Withaferin A (WA) is derived from the medical plant Withania somnifera (commonly known as ashwagandha or Indian winter cherry), which has been safely used for centuries in Indian Ayurvedic medicine for treatment of different ailments. Suppresion of angiogenisis, alteration of cytoskeletal architecture, and inhibition of proteasomal activity by WA has also been documented.
- Hypoxia-inducible factor-1 (HIF-1) is a transcriptional complex that is activated in response to hypoxia and growth factors. HIF-1 plays a central role in tumor progression, invasion, and metastasis.