1. Differences Between Necrosis and Necroptosis

    Differences Between Necrosis and Necroptosis
    Cell death has traditionally been subdivided into regulated (apoptosis) and unregulated (necrosis) forms. While apoptosis has always been recognized to be a pathway of highly orchestrated signaling events, necrosis or necrotic cell death is known as a fortuitous and unregulated means of cell death that is induced by nonspecific and nonphysiological stress.
  2. Valinomycin Ionophore: Frequently Asked Questions

    Valinomycin Ionophore: Frequently Asked Questions
    Valinomycin is a potent antibiotic which acts as a potassium (K+) ionophore. Induces K+ conductivity in cell membranes. Also active in vitro against Mycobacterium Tuberculosis, and as an apoptosis inducer. Valinomycin is obtained from the cells of several Streptomyces strains, among which "S. tsusimaensis" and S. fulvissimus.
  3. What is Thapsigargin? Frequently Asked Questions

    What is Thapsigargin? Frequently Asked Questions
    Thapsigargin is derived from the plant Thapsia garganica that produces tumor promoters. This effect is a result of emptying the intracellular calcium stores, which leads to a chain of events that causes apoptosis. Mechanism of Action Chemical structure of Thapsigargin Thapsigargin is an inhibitor of sarco endoplasmic reticulum Ca2 ATPase (SERCA). It pumps calcium ions from the cytoplasm into the lumen...
  4. Bafilomycin as a Cancer Treatment

    Bafilomycin as a Cancer Treatment
    Bafilomycins are a family of toxic macrolide antibiotics isolated from Streptomyces species. AG Scientific offers several high-quality bafilomycin products. Bafilomycins at AG Scientific Product Number Product Name B-1183 Bafilomycin A1 B-1185 Bafilomycin B1 B-1245 Bafilomycin B2 B-2535 Bafilomycin C1 B-2537 Bafilomycin D Bafilomycins in Cancer Research The most commonly used bafilomycin is bafilomycin A1 (Baf-A1). Baf-A1 is an autophagy inhibitor...
  5. CHIR 99021 GSK3 Inhibitor’s Role in Stem Cell Research

    CHIR 99021 GSK3 Inhibitor’s Role in Stem Cell Research
    Stem cell therapies are the leading and most sensational topic in the world of scientific research. The excitement is due to the huge potential these cells have in curing human diseases. What are stem cells? They are undifferentiated cells in human body that are capable of differentiating into specialized cell types. Stem cells differentiate into different cell types during early...
  6. Thapsigargin Applications: Glioblastoma Multiforme Studies

    Thapsigargin Applications: Glioblastoma Multiforme Studies
    Glioblastoma multiforme is the most aggressive and malignant form of gliomas, a group of tumors arising from glial cells of the brain. Glioblastomas are very difficult to treat due to the diffused nature of the tumor itself. The tumor cells have a distinct invasive feature of spreading and diffusing into different parts of the brain. This characteristic feature of these...
  7. A Promising Cancer Therapy: Thapsigargin's Anti-Cancer Roles

    A Promising Cancer Therapy: Thapsigargin's Anti-Cancer Roles
    Thapsia Garganica is a common Mediterranean weed  highly toxic to sheep and cattle, thus earning the nickname death carrot. Thapsigargin is a natural cytotoxin derived from the plant Thapsia Graganica. Oncologists Samuel Denmeade at Johns Hopkins University, Baltimore and his team has extensively researched methods to harness thapsigargin's toxicity, and develop, as result, a potential and novel anti-cancer therapeutic and...
  8. Learn how Buthionine Inhibits Cancer Cells

    L-Buthionine sulfoximine is a specific γ-glutamylcysteine synthetase inhibitor that blocks the rate-limiting step of glutathionine biosynthesis and in doing so depletes the intracellular glutathionine pool in both cultured cells and in whole animals. Glutathionine (GSH) is a water-soluble tripeptide composed of glutamine, cysteine, and glycine. Reduced glutathione is the most abundant intracellular small molecule thiol present in mammalian cells and it serves as a potent intracellular antioxidant protecting cells from toxins such free radicals. Changes in glutathionine homeostasis have been implicated in the etiology and progression of a
  9. MG-132: Fighting Cancer Cells

    Tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) is a promising anticancer agent because it induces apoptosis in cancer cells but not in normal cells.
  10. Why Caspases are the executioners of apoptosis?

    Apoptosis, or cell suicide, is a form of cell death that is morphologically and biochemically distinct from necrosis. Although the concept of apoptosis was introduced 43 years ago (Kerr et al 1972), the mechanisms of how apoptosis is initiated and executed remained unclear until recently.

Items 1 to 10 of 15 total

To Top