Ascomycin, also called Immunomycin, FR-900520, FK520, is an ethyl analog of tacrolimus (FK506) with strong immunosuppressant properties. Ascomycin acts by binding to immunophilins, especially macrophilin-12. It appears that Ascomycin inhibits the production of Th1 (interferon- and IL-2) and Th2 (IL-4 and IL-10) cytokines. Additionally, ascomycin preferentially inhibits the activation of mast cells, an important cellular component of the atopic response. Ascomycin produces a more selective immunomodulatory effect in that it inhibits the elicitation phase of allergic contact dermatitis but does not impair the primary immune response when administered systemically.
- A.G. Scientific is a leading supplier of the immunosuppressant, FK-506 commonly known as Tacrolimus. It is well known for its ability to prevent allograft rejection after transplantation.FK 506 resized 600 A.G.Scientific has long been established as a leading research supplier in the field of fermentation derived secondary metabolites.