1. Hydroxychloroquine: Misconceptions in the Media

    Hydroxychloroquine: Misconceptions in the Media
    Hydroxychloroquine: Misconceptions in the Media It’s hard to miss hearing the word “hydroxychloroquine” being associated with coronavirus in the news right now.  Hydroxychloroquine is being touted as a “game changer” in treating coronavirus by people in the current US administration who are not medical professionals. This drug has a similar structure to a previously established drug called CQ (N4-(7-Chloro-4-quinolinyl)-N1,N1-diethyl-1,4-pentanediamine), which...
  2. SMER28- Enhancer of Autophagy

    SMER28- Enhancer of Autophagy
    SMER28 is a small-molecule enhancer (SMER) of autophagy that increases autophagosome synthesis and enhances clearance of aggregate-prone substrates, including those relevant to Huntington's, Parkinson's, and Alzheimer's diseases. It is a positive regulator of autophagy in a mechanism independent from the mTOR pathway. It increases autophagosome synthesis and enhances the clearance of model autophagy substrates such as A53T a-synuclein and mutant...

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