1. Bestatin's new role: Enzymatic insight via Activity-Based Probe, ABP

    The need for improved tools within the proteomic field is an ongoing, rapidly evolving endeavour. Today, I detail a novel approach utilizing a chemical biology strategy denoted as activity-based probes (ABPs). The aim is to functionally profile enzyme classes in their activity state. In the following example, metallo-aminopeptidases was profiled based upon synthesizing the bestatin inhibitor scaffold. It is the...

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