1. Beta-Lactamase and Microbial Antibiotic Resistance

    Beta-Lactamase and Microbial Antibiotic Resistance
    β-Lactamases continue to be the leading cause of resistance to β-lactam antibiotics among gram-negative bacteria. In recent years there has been an increased incidence and prevalence of extended-spectrum β-lactamases (ESBLs), enzymes that hydrolyze and cause resistance to oxyimino-cephalosporins and aztreonam.
  2. Top 7 FAQs About Beta-Lactamase

    Top 7 FAQs About Beta-Lactamase
    Top 7 FAQs About Beta-Lactamase As a core structure in many antibiotics, the beta-lactam ring is a cyclic amide. Beta-lactam antibiotics almost universally inhibit bacterial cell wall synthesis and thus induce the destruction of bacterial cells. Bacteria have evolved an enzyme that combats this antibiotic and increases resistance to death induced by antibiotic means: the beta-lactamase enzyme. Beta-lactamase enzymes can...

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