Bafilomycins are a family of toxic macrolide antibiotics isolated from Streptomyces species. AG Scientific offers several high-quality bafilomycin products. Bafilomycins at AG Scientific Product Number Product Name B-1183 Bafilomycin A1 B-1185 Bafilomycin B1 B-1245 Bafilomycin B2 B-2535 Bafilomycin C1 B-2537 Bafilomycin D Bafilomycins in Cancer Research The most commonly used bafilomycin is bafilomycin A1 (Baf-A1). Baf-A1 is an autophagy inhibitor...
- To lead a healthy lifestyle it is essential to eat healthy and exercise regularly. People who exercise regularly would often reach a point during their workout session, where they feel extremely exhausted and could not carry on any further. Fatigue sets in when lactate (a form of Lactic acid) builds up in the muscles. Lactic acid is an end product...
- Lactic acid is an end product of Glycolysis under anaerobic conditions. There are 2 optically active stereoisomers of lactic acid: L-Lactic acid produced by muscles during anaerobic glycolysis and by most of the lactic acid bacteria. D-Lactic acid Produced by some bacteria, plants and algae. Lactate and lactic acid detection is very important in: Medicine Indicator of ischemia in critical care...
- Cancers that become resistant to an important class of drugs might be made vulnerable by tweaking the immune system, a team led by UCSD researcher Napolene Ferrara has found.
- Rapamycin, also known as sirolimus, is an immunosuppressant drug used to prevent rejection in organ transplantation; it is especially useful in kidney transplants.
- MECHANISM OF ACTION: epirubicidin, anthracycline, antibiotics, anticancerThe mechanism of action of epirubicin appears to be related to its ability to bind to nucleic acids. It forms a complex with DNA by intercalation between base pairs, resulting in inhibition of DNA and RNA synthesis. Intercalation also triggers DNA cleavage by topoisomerase II, resulting in cytocidal activity.
- Ansamycins is a family of secondary metabolites that show antimicrobial activity against many gram-positive and some gram-negative bacteria and includes various compounds, among which: streptovaricins and rifamycins. In addition, these compounds demonstrate antiviral activity towards bacteriophages and poxviruses.
- Paclitaxel, Taxus brevifolia, commonly known as the Pacific yew, is a member of the yew family (Taxaceae). It is a small, slow growing evergreen tree native to the northwestern United States (Wheeler et al., 1992).
- Cycloheximide (CHX) can contribute to apoptotic processes, either in conjunction with another agent (e.g. tumor necrosis factor-Î±) or on its own. The apoptotic process is now known to involve the well orchestrated interactions of cell death receptors, death receptor adaptors, caspases, and Bcl-2 family members.