1. n-Dodecyl-β-D-maltopyranoside

    n-Dodecyl-β-D-maltopyranoside
    Any scientist involved in proteomics or protein engineering, will stand by the fact that detergents are indispensable tools for isolation and solubilization of integral membrane proteins and protein complexes from biological membranes. For these studies, it is very important to have intact protein structures in their native biological form in order to evaluate their structure, function, dynamics and binding of...
  2. Detergents: Important Tools for Membrane Protein Purification

    Detergents: Important Tools for Membrane Protein Purification
    Membrane Proteins Proteins control almost all functions of a cell. Any mutation in protein structure or any issue hampering protein functionality can lead to abnormal cell processes, which can in turn result in disease. Therefore it is very important to meticulously learn and get a better understanding of proteins in order to find therapies for diseases plaguing humanity. Integral membrane...
  3. Piperlonguminine: Potential Treatment For Alzheimer's Disease

    Piperlonguminine is a potential novel therapeutic agent for Alzheimer's disease.  Extracellular deposits of Aβ in senile plaques of the cerebral cortex are known to be hallmarks of Alzheimer's disease. Recent studies show that a mix of piperlonguminine and dihydropiperlonguminine significantly inhibit the expression of Amyloid Precursor Protein (APP). The decreased production of the peptide Amyloid β (Aβ) in SK-N-SH cells...
  4. Protein Solubilizers aka Protein Biodetergents

    Non-ionic detergents contain uncharged, hydrophilic head groups that consist of eithermicelle polyoxyethylene moieties as in TWEEN and TRITON or glycosidic groups as in octyl glucoside and dodecyl maltoside. In general, non-ionic detergents are better suited for breaking lipid-lipid and lipid-protein interactions than protein-protein interactions.

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