1. What are Bio Detergents? Detergents are soluble amphiphilic molecules that are able to incorporate to liposomes and cell membranes. They are essential tools for the study of biological membranes, as they are frequently used to solubilize membrane proteins and to investigate the interactions among membrane lipid components. 2. What are the different types of biological detergents? Ionic detergents...
Piperlonguminine is a potential novel therapeutic agent for Alzheimer's disease. Extracellular deposits of AÎ² in senile plaques of the cerebral cortex are known to be hallmarks of Alzheimer's disease. Recent studies show that a mix of piperlonguminine and dihydropiperlonguminine significantly inhibit the expression of Amyloid Precursor Protein (APP). The decreased production of the peptide Amyloid Î² (AÎ²) in SK-N-SH cells...
The method of detergent removal can be an important consideration. If dialysis is to be employed, a detergent with a high CMC is clearly preferred. Alternatively, if ion exchange chromatography is utilized, a non-ionic detergent (e.g. n-Octyl-Î²-D-Glucopyranoside, OG, O-1036 see structure,OCTYL-GLUCOSIDE DDM, D-1304) or a sulfobetaines.