1. Alcohol, Cancer, and Dying: Research 2016

    Alcohol, Cancer, and Dying: Research 2016
    2016 is a big year for cancer research! Research from across the world has been reporting a mix of good and bad, with the scariest showing a list of alcohol-related cancer diseases and the best news of all showing a trick to cheat death. Do you drink alcohol? Did you know that alcohol can cause cancer of the oropharynx, larynx...
  2. Biomarker Latest Application: CNS Development

    Biomarker Latest Application: CNS Development
    Central nervous system (CNS) infections are an important public health concern worldwide. They occur commonly and are associated with high rates of mortality and morbidity. Most deaths related to CNS infections are the result of cerebral tissue injury. Neurological symptoms in survivors include physical, sensory, and cognitive disability, all of which may be permanent. Once bacteria enter the CNS, the...
  3. Neurological biomarkers in the perioperative period

    Delirium, cerebrovascular accidents, postoperative cognitive dysfunction (POCD), and spinal cord ischaemia are among the most devastating perioperative neurological outcomes. In an attempt to address these outcomes, it would be helpful to identify patients at risk, predict their short- and long-term outcomes, monitor them perioperatively, and possibly apply neuroprotective interventions aimed at improving such outcomes. There is no available methodology to...

    AEBSF or 4-(2-Aminoethyl) benzenesulfonyl fluoride hydrochloride is a water-soluble, irreversible serine protease inhibitor with a molecular weight of 239.5 Da. It inhibits proteases like chymotrypsin, kallikrein, plasmin, thrombin, and trypsin. The specificity is similar to the inhibitor PMSF, nevertheless, AEBSF is more stable at low pH values. Typical usage is 0.1 - 1.0 mM. AEBSF is used as a protease...
  5. Proteomics for Cancer Biomarker Discovery - Pt. 1

    Cancer remains a major public health challenge despite progress in detection and therapy. A large portion of the US population will develop cancer during their lifetime, with ∼500 000 individuals dying annually from the disease. The race to obtain control over the disease process is gaining speed and focus. From biotechnology to chemistry, from applied physics to software, increasing resources are being brought to bear on the goals of prevention and reducing mortality. Innovations and applications of biotechnology have allowed the exploitation of biological processes in an effort to study pathogenesis at the molecular level. Novel technologies that are designed to advance the molecular analyses of healthy and diseased human cells are poised to revolutionize the field of health and disease. Advances in the fields of genomics and proteomics are hoped to provide insights into the molecular complexity of the disease process and thus enable the development of tools to help in treatment as well as in detection and prevention.
  6. MicroRNAs: from single biomarkers to re-wired networks

    The complexity of higher organisms is regulated through the coordinated control of biological networks, including miRNAs. Computational networks have previously been generated using miRNA array data. For the first time, we have applied a similar approach to circulating miRNAs.

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