Activation of the hedgehog pathway has been implicated in the development of cancers in various organs, including brain, lung, mammary gland, prostate and skin. Basal cell carcinoma, the most common form of cancerous malignancy, has the closest association with hedgehog signaling.
Cycloheximide (CHX) can contribute to apoptotic processes, either in conjunction with another agent (e.g. tumor necrosis factor-Î±) or on its own. The apoptotic process is now known to involve the well orchestrated interactions of cell death receptors, death receptor adaptors, caspases, and Bcl-2 family members.