Central nervous system (CNS) infections are an important public health concern worldwide. They occur commonly and are associated with high rates of mortality and morbidity. Most deaths related to CNS infections are the result of cerebral tissue injury. Neurological symptoms in survivors include physical, sensory, and cognitive disability, all of which may be permanent. Once bacteria enter the CNS, the...
PURPOSE: Some antibiotics were known to exert neuroprotective effects in the animal model of hypoxic-ischemic (H-I) brain injury, but the mechanism is still unclear. A recent study reported that geneticin (G418), an aminoglycoside antibiotic, increased survival of human breast cancer cells by suppressing apoptosis. We investigated the neuroprotective effects of systemically administrated geneticin via anti-apoptosis following the H-I brain injury.