1. A23187: A Carboxylic Acid Antibiotic Which Simultaneously Uncouples Oxidative Phosphorylation and Inhibits ATPase

    OVERVIEW A23187 is a carboxylic acid antibiotic which simultaneously uncouples oxidative phosphorylation and inhibits ATPase of rat liver mitochondria incubated in a magnesium-free medium. The antibiotic acts as a freely mobile carrier to transport calcium and magnesium, but not potassium, from an aqueous medium buffered at pH 7.4 into a bulk organic phase. A23187 causes a progressive release of endogenous...

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