• Anthracyclines: Anti-Cancer Compounds 2018-12-03 09:00:57 Anthracyclines are anticancer compounds that were originally derived from Streptomyces and their anti-tumor activitieswere established in the 1960s. Anthracyclines are red aromatic polyketides and occur in variety of forms due to the structural differences in the aglycone and the different sugar res Beaker and pipette
  • Genomics and Cancer: The Search for a Cure 2012-11-29 15:37:53 Over the past two decades, dramatic progress has been made in many areas of medicine where hope once seemed out of reach. An infectious disease like HIV, considered intractable in the 1990s, is now controllable with anti-retroviral therapy; and the right combination of antibiotics can similarly cont
  • Roscovitine: A Highly Selective CDK Inhibitor With Promising Oncology 2012-07-25 12:33:54 (R)-Roscovitine is often referred to as a “selective inhibitor of cyclin-dependent kinases.” Besides its use as a biological tool in cell cycle, neuronal functions, and apoptosis studies, it is currently evaluated as a potential drug to treat cancers, neurodegenerative diseases, viral in
  • GSK-3, WNT Signaling: Cancer Treatment 2012-07-10 12:08:29 MECHANISM The Wnt pathway involves a large number of proteins that can regulate the production of Wnt signaling molecules, their interactions with receptors on target cells and the physiological responses of target cells that result from the exposure of cells to the extracellular Wnt ligands. Althou
  • Hemocyanins: Cancer Application 2012-07-09 11:16:33 Keyhole limpet hemocyanin is an extremely large, heterogeneous glycosylated protein consisting of subunits with a molecular weight of 350,000 and 390,000 in aggregates with molecular weights of 4,500,000-13,000,000.
  • Cantharidin: Used in Cancer Treatments and Inhibits PP1 & PP2A 2012-06-18 12:48:00 Cantharidin was first isolated in 1810 by Pierre Robiquet, a French chemist then living in Paris, from Lytta vesicatoria. Secreted by many species of blister beetle, most notably by the 'Spanish fly' (Lytta vesicatoria), cantharidin inhibits protein phosphatases 1 and 2A (PP1, PP2A).