Cell death has traditionally been subdivided into regulated (apoptosis) and unregulated (necrosis) forms. While apoptosis has always been recognized to be a pathway of highly orchestrated signaling events, necrosis or necrotic cell death is known as a fortuitous and unregulated means of cell death that is induced by nonspecific and nonphysiological stress.
- Apoptosis, or cell suicide, is a form of cell death that is morphologically and biochemically distinct from necrosis. Although the concept of apoptosis was introduced 43 years ago (Kerr et al 1972), the mechanisms of how apoptosis is initiated and executed remained unclear until recently.
- There is extensive evidence that necrosis plays a prominent role in a wide range of human pathological conditions, such as myocardial infarct, ischemic injury and neurodegeneration. Therefore, development of necrosis inhibitors is of high interest.
- Necrosis is the premature death of cells in living tissue and can be caused by external factors to the cell or tissue, such as infection, toxins, cancer, infarction, poisons, ROS (Reactive Oxygen Species), inflammation or trauma. Necrosis inhibitors can counteract the effects that may normally cause cell death. Historically, cell death has been subdivided into regulated (apoptosis, AKA programmed...