1. CHIR 99021 GSK3 Inhibitor’s Role in Stem Cell Research

    CHIR 99021 GSK3 Inhibitor’s Role in Stem Cell Research
    Stem cell therapies are the leading and most sensational topic in the world of scientific research. The excitement is due to the huge potential these cells have in curing human diseases. What are stem cells? They are undifferentiated cells in human body that are capable of differentiating into specialized cell types. Stem cells differentiate into different cell types during early...
  2. Cancer Treatment Combination of Paclitaxel, Rapamycin and 17-AAG

    The Wisconsin Alumni Research Foundation (WARF) is seeking commercial partners interested in developing a composition of the synergistic anticancer agents rapamycin, paclitaxel and 17-AAG, encapsulated and solubilized by nontoxic, nanoscale PEG-b-PLA micelles.

    17-allylamino,17-demethoxygeldanamycin (17-AAG) is a novel anticancer drug that is a less toxic analogue of the geldanamycin which binds to Hsp90 and alters its function. HSP90 client proteins play important roles in the regulation of the cell cycle, cell growth, cell survival, apoptosis, and oncogenesis.

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