1. The CHIR99021 GSK-3 Inhibitor Mechanism

    The CHIR99021 GSK-3 Inhibitor Mechanism
    The CHIR99021 GSK-3 Inhibitor is both potent and selective. Small membrane-permeable molecules are widely utilized for maintenance and differentiation of embryonic stem cells (ES) of different species. Glycogen synthase kinase 3 (GSK3) activates the Wnt/beta-catenin pathway when targeted for inhibition. GSK3 is a conserved signaling molecule with essential roles in diverse biological processes. GSK3 activity has been linked to a...
  2. Unlocking New Diagnostic Tools from Diabetes

    In today’s modern world, the recent dramatic increase in the number of patients with type 2 diabetes indicates an unchecked global epidemic is at hand. In 2011 the U.S. Centers for Disease Control and Prevention estimated that about 8.3% of the American population (25.8 million people) had diabetes—while 7 million were unaware of it.

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