Staurprimde is a semi-synthetic analog of the staurosporine family of indolocarbazoles. The study conducted by Zhu, et al (2009) found Stauprimide increases efficiency of directed Embryonic Stem Cells (ESC) differentiation. Stauprimide promoted induction of Sox17 / Sox 7 cells in both mouse and human ESC, and also helped induce extensive endoderm differentiation markers in the mouse ESC. Early stauprimide treatment was found to enhance later differentiation of the cells toward hepatic and pancreatic lineages. Additionally the study shows Staurpimide binds NME2, impairing nuclear localiz
TGF-Î² superfamily members signal through a receptor complex comprising a type II and type I receptor, both serine/threonine kinases. Here, we characterize a small molecule inhibitor (SB-431542) that was identified as an inhibitor of activin receptor-like kinase (ALK)5 (the TGF-Î² type I receptor).