Following more than four decades of intense research, scientists may be closer to deciphering the precise mechanisms at work in stem cell development and differentiation, a recent paper published in the Journal of Molecular Endocrinology reports. Stem cells control organ homeostasis, growth, and self-regulation. This is done by relying on a network of short-range, localized transcription factors (TFs). Transcription factors are a major effector of physiological changes and wield significant influence on stem cell behavior in many ways.
"There are quite a few examples that we now know of where the activity of genes can be affected in the long term by environmental factors. And in some cases the environment of an individual can actually affect the biology or physiology of their offspring but there is no change to the genome sequence."