Discovery of Rapamycin Rapamycin is a macrocyclic triene antibiotic that binds to the cytosolic protein FK-binding protein 12 (FKBP12) and inhibits mTOR pathway by directly binding to the mTOR Complex 1 (mTORC1). It is a potent immunosuppressant having a variety of uses both in vitro and in vivo and is used to prevent organ rejection after transplantation. Chemical structure of...
- A.G. Scientific is a leading supplier of the immunosuppressant, FK-506 commonly known as Tacrolimus. It is well known for its ability to prevent allograft rejection after transplantation.FK 506 resized 600 A.G.Scientific has long been established as a leading research supplier in the field of fermentation derived secondary metabolites.