Genetic engineering is at the forefront of biotechnology research to treat the most devastating diseases. This technology promises to eradicate genetic mutations that are often fatal and cannot be treated with modern medicine. Let's first understand what exactly genetic engineering is and how it can treat hereditary diseases. What Is Gene Editing? Gene editing is the process of using genetic...
- G-418 (Geneticin) is an aminoglycoside antibiotic similar in structure to gentamicin B1. It is produced by Micromonospora rhodorangea. G418 blocks polypeptide synthesis by inhibiting the elongation step in both prokaryotic and eukaryotic cells.
- PURPOSE: Some antibiotics were known to exert neuroprotective effects in the animal model of hypoxic-ischemic (H-I) brain injury, but the mechanism is still unclear. A recent study reported that geneticin (G418), an aminoglycoside antibiotic, increased survival of human breast cancer cells by suppressing apoptosis. We investigated the neuroprotective effects of systemically administrated geneticin via anti-apoptosis following the H-I brain injury.