1. Neomycin Applications

    Neomycin Applications
    Neomycins are a family of broad-spectrum highly toxic antibiotics produced by Streptomyces fradiae. Neomycin usually exists as a complex composed of two stereoisomers, neomycin B and neomycin C, which are the two active components. A third component, neomycin A, which is a degradation product, is present in small quantities. Neomycin C was isolated by DUTCHER et al. Neomycin C is...
  2. DNA Sequencing of Cancer: What Have We Learned So Far?

    So much as science is an art, it is really an art of seeing and hearing nature in its most minute form in any setting, big or small. Sometimes nature gives us clues in the many meticulous observations noted by scientists. Other times, the absence of any expected phenomenon can be just as enlightening to the researcher.
  3. Gene Trek: Clinical Impacts of Next Generation Sequencing

    Next generations sequencing (NGS) has expanded beyond research applications to deliver clinically actionable information that can effectively guide therapeutic decision-making. Cancer researchers today seek to translate the immense volume of genomic data to clinical applications [1].
  4. Genomic Sequencing for Cancer Diagnosis and Therapy

    In 2012, 8.2 million people died of cancer – an estimated 14.6% of all deaths worldwide. The number of cancer diagnoses globally is projected to increase 57% (approximately 8 million new cases) between now and 2030, influenced in part by an aging population. That same year, in 2012, the World Health Organization announced cancer had officially replaced heart disease as the primary cause of death in many developed and developing countries worldwide (http://www.who.int/mediacentre/factsheets/fs297/en/). This fact is fueling increased demand for research and public health campaigns to fight cancer both here at home and abroad. This article probes the discoveries leading up to the invention of whole-genome sequencing used widely today.
  5. Zinc-Finger Nucleases: Expanding the Gene Editor's Tool Kit

    Zinc finger nucleases (ZFNs) have become useful reagents when it comes to manipulating the genomes in plants and animals. As a result, they are becoming increasingly widespread throughout academic campuses and industrial applications worldwide.
  6. Genome Engineering using CRISPR (Cas9)

    DNA (Deoxyribonucleic Acid) is often referred to as the blueprint for life. This is because DNA is made up of genes, which encode for the information required to produce functional proteins. describe the imageFor decades it was believed that only higher order, multi-cellular life possessed the cellular machinery necessary to provide its host with adaptive immunity. We now know that DNA is routinely edited in bacteria as part of their own adaptive immune response, which is made possible largely because of an enzyme called CRISPR – pronounced ‘crisper’.

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