or the last 18 years, AG Scientific has been a leading manufacturer, retail supplier and wholesaler of g-418, GeneticinÂ®. Our success with a combination of fermentation & synthesis that has allowed us to build a catalog of over 180 antibiotics and a customer base of researchers, catalog biochemical distributors and cell media manufacturers worldwide.
PURPOSE: Some antibiotics were known to exert neuroprotective effects in the animal model of hypoxic-ischemic (H-I) brain injury, but the mechanism is still unclear. A recent study reported that geneticin (G418), an aminoglycoside antibiotic, increased survival of human breast cancer cells by suppressing apoptosis. We investigated the neuroprotective effects of systemically administrated geneticin via anti-apoptosis following the H-I brain injury.