Scientists at Case Western University, under the support in part by the Public Health Service Grant, was able to map the allosteric site in Cholesterol Hydroxylase CYP46A1 for efavirenz, a drug used to treat HIV infections, that stimulates enzyme activity. What they Found CYP46A1 is an enzyme responsible for 80 percent of the cholesterol breakdown in the human brain. Efavirenz...
-
Protease Inhibitors: Killing Viral Replication
What Is a Protease Inhibitor? To best explain what a protease inhibitor is, let's start with a basic review of the biology of viruses, such as HIV. Firstly, HIV is a virus that attacks the immune system by infecting cells of the immune system. The infection does not kill the cell immediately, but HIV forces the infected cell to make...