1. Kainic Acid: An Excitatory Amino Acid Receptor Agonist Selective for Kainate Receptor Subtype

    OVERVIEW Kainic Acid is a marine product, derived from the red marine alga Digenea Simplex. Kainic Acid is an excitatory amino acid receptor agonist selective for kainate receptor subtype; conformationally restricted analog of L-glutamic acid. Kainic acid is a potent central nervous system stimulant, and has been developed as the prototype neuroexcitatory amino acid for the induction of seizures in experimental animals, at a typical dose of 10-30 mg/kg in mice. Kainic acid is neuroexcitotoxic and epileptogenic, acting through specific kainate receptors.

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