1. Pathology Research Using Mitophagy Modulators

    Pathology Research Using Mitophagy Modulators
    Pathology Research Using Mitophagy Modulators When you hear “small things with big impact”, do you immediately think of mitochondria and mitophagy modulators? Probably not! But these little organelles are champions of cell regulation.  Among their functions is regulating the energy of the cell as well as cell death. And just as mitochondria are responsible for cell function, mitophagy is responsible...
  2. A23187: Uncouples Oxidative Phosphorylation and Inhibits ATPase

    A23187: Uncouples Oxidative Phosphorylation and Inhibits ATPase Chemical structure of calcium ionophore A23187 A23187 is a carboxylic acid antibiotic which simultaneously uncouples oxidative phosphorylation and inhibits ATPase of rat liver mitochondria incubated in a magnesium-free medium. The antibiotic acts as a freely mobile carrier to transport calcium and magnesium, but not potassium, from an aqueous medium buffered at pH 7.4...

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