• Polyene Macrolide Antibiotics 2018-12-26 13:31:12 It has been 60 years since the first report of erythromycin in 1952. Over the course of this 60 years the macrolide antibiotics—14- and 16-membered macrolactams—have been followed at intervals by the lincosamides, streptogramins, azalides and now the ketolides.