1. Bestatin (Ubenimex): Applications in Life Science Research

    Bestatin (Ubenimex): Applications in Life Science Research
    Bestatin, also known as Ubenimex, is a competitive protease inhibitor. It is an inhibitor of aminopeptidase B, leukotriene A4 hydrolase, aminopeptidase N. It is being studied for use in the treatment of acute myelocytic leukemia.
  2. Fighting HIV with Protease Inhibitors

    Fighting HIV with Protease Inhibitors
    HIV relies on the host cell it injects itself into to continue the cycle. By implicating road blocks in this process through protease inhibitors, there is a possibility of halting the replication and spread of the HIV virus. 7 Steps of the HIV Life Cycle: The first step of the HIV cycle is binding, when the virus first attaches to...
  3. Protease Inhibitors: Killing Viral Replication

    Protease Inhibitors: Killing Viral Replication
    What Is a Protease Inhibitor? To best explain what a protease inhibitor is, let's start with a basic review of the biology of viruses, such as HIV. Firstly, HIV is a virus that attacks the immune system by infecting cells of the immune system. The infection does not kill the cell immediately, but HIV forces the infected cell to make...
  4. AEBSF AS A KEY BIOMARKER

    AEBSF or 4-(2-Aminoethyl) benzenesulfonyl fluoride hydrochloride is a water-soluble, irreversible serine protease inhibitor with a molecular weight of 239.5 Da. It inhibits proteases like chymotrypsin, kallikrein, plasmin, thrombin, and trypsin. The specificity is similar to the inhibitor PMSF, nevertheless, AEBSF is more stable at low pH values. Typical usage is 0.1 - 1.0 mM. AEBSF is used as a protease...
  5. E-64, Cysteine Protease Inhibitor: Frequently Asked Questions

    E-64, Cysteine Protease Inhibitor: Frequently Asked Questions
    Irreversible, potent and highly selective inhibitor of cysteine proteases. Does not affect cysteine residues in other enzymes. Acts by forming a thioether bond with thiol of the active cysteine. E-64 will not inhibit serine proteases (except trypsin) inhibits activation-induced programmed cell death and restores defective immune responses in HIV+ donors. Specific active site titrant.

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