1. G418 Sulfate (Geneticin): Protocols and FAQs

    G418 Sulfate (Geneticin): Protocols and FAQs
    or the last 18 years, AG Scientific has been a leading manufacturer, retail supplier and wholesaler of g-418, Geneticin®. Our success with a combination of fermentation & synthesis that has allowed us to build a catalog of over 180 antibiotics and a customer base of researchers, catalog biochemical distributors and cell media manufacturers worldwide.
  2. n-Dodecyl-β-D-maltopyranoside

    Any scientist involved in proteomics or protein engineering, will stand by the fact that detergents are indispensable tools for isolation and solubilization of integral membrane proteins and protein complexes from biological membranes. For these studies, it is very important to have intact protein structures in their native biological form in order to evaluate their structure, function, dynamics and binding of...
  3. Detergents: Important Tools for Membrane Protein Purification

    Detergents: Important Tools for Membrane Protein Purification
    Membrane Proteins Proteins control almost all functions of a cell. Any mutation in protein structure or any issue hampering protein functionality can lead to abnormal cell processes, which can in turn result in disease. Therefore it is very important to meticulously learn and get a better understanding of proteins in order to find therapies for diseases plaguing humanity. Integral membrane...
  4. Proteomics for Cancer Biomarker Discovery - Pt. 1

    Cancer remains a major public health challenge despite progress in detection and therapy. A large portion of the US population will develop cancer during their lifetime, with ∼500 000 individuals dying annually from the disease. The race to obtain control over the disease process is gaining speed and focus. From biotechnology to chemistry, from applied physics to software, increasing resources are being brought to bear on the goals of prevention and reducing mortality. Innovations and applications of biotechnology have allowed the exploitation of biological processes in an effort to study pathogenesis at the molecular level. Novel technologies that are designed to advance the molecular analyses of healthy and diseased human cells are poised to revolutionize the field of health and disease. Advances in the fields of genomics and proteomics are hoped to provide insights into the molecular complexity of the disease process and thus enable the development of tools to help in treatment as well as in detection and prevention.
  5. Proteomics: Pathways and Biomarkers

    Proteomics Proteomics is about measuring proteins, and ideally, about measuring many of them. Not surprisingly, given the universal importance of proteins in biological systems and the variety of their properties when employed as machines, signals, structural materials, and food, proteomics has enabled real progress in many areas of biology while falling short in others. Fortunately, we are beginning to understand...
  6. Proteomics: addressing the challenges of multiple myeloma

    Multiple myeloma (MM) is a malignancy of terminally differentiated B-lymphocytes that accounts for ∼13% of all hematologic cancers. Despite a wealth of knowledge describing the molecular biology of MM as well as significant advances in therapeutics, this disease remains incurable.
  7. How to Use Proteases for Protein Proteolysis

    How to Use Protease/s for Protein Proteolysis Protein Proteolysis refers to the use of hydrochloric acid to destroy peptide bonds between the amino acids that make up a protein. When carried out with proteases (also known as proteinases), which are enzymes, the process is termed proteolysis. Depending on how efficient the enzyme is or what links it breaks, the proteolysis can be limited or unlimited. Proteolysis can begin either from one end of the chain of amino acids that comprise the protein or somewhere in the middle of it. Unlimited proteolysis produces individual amino acids while limited proteolysis produces short chains of polypeptides.

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