1. The CHIR99021 GSK-3 Inhibitor Mechanism

    The CHIR99021 GSK-3 Inhibitor Mechanism
    The CHIR99021 GSK-3 Inhibitor is both potent and selective. Small membrane-permeable molecules are widely utilized for maintenance and differentiation of embryonic stem cells (ES) of different species. Glycogen synthase kinase 3 (GSK3) activates the Wnt/beta-catenin pathway when targeted for inhibition. GSK3 is a conserved signaling molecule with essential roles in diverse biological processes. GSK3 activity has been linked to a...

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