1. SMER28- Enhancer of Autophagy

    SMER28- Enhancer of Autophagy
    SMER28 is a small-molecule enhancer (SMER) of autophagy that increases autophagosome synthesis and enhances clearance of aggregate-prone substrates, including those relevant to Huntington's, Parkinson's, and Alzheimer's diseases. It is a positive regulator of autophagy in a mechanism independent from the mTOR pathway. It increases autophagosome synthesis and enhances the clearance of model autophagy substrates such as A53T a-synuclein and mutant...

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