Any questions about Inhibitor CHIR99021? See all about it in the post below. What is inhibitor CHIR99021? CHIR99021 (CT99021), is also known as 6-amino]ethyl]amino]-3-pyridinecarbonitrile and CT99021. It is the most potent and selective inhibitor of GSK3. CHIR99021 is an aminopyrimidine derivative. It inhibits GSK3 Î² and GSK3 Î±. It also functions as a WNT activator. It is the most selective...
Staurprimde is a semi-synthetic analog of the staurosporine family of indolocarbazoles. The study conducted by Zhu, et al (2009) found Stauprimide increases efficiency of directed Embryonic Stem Cells (ESC) differentiation. Stauprimide promoted induction of Sox17 / Sox 7 cells in both mouse and human ESC, and also helped induce extensive endoderm differentiation markers in the mouse ESC. Early stauprimide treatment was found to enhance later differentiation of the cells toward hepatic and pancreatic lineages. Additionally the study shows Staurpimide binds NME2, impairing nuclear localiz
Hypoxia-inducible factor-1 (HIF-1) is a transcriptional complex that is activated in response to hypoxia and growth factors. HIF-1 plays a central role in tumor progression, invasion, and metastasis.