Producing stem cells has always been a convoluted process. Thatâ€™s why the discovery of key transcriptional networks are helping to pave the way for new culturing methods and further advancements in the field of cell therapy (see also,Pluripotent Stem Cells â€“ What we know today) .
Following more than four decades of intense research, scientists may be closer to deciphering the precise mechanisms at work in stem cell development and differentiation, a recent paper published in the Journal of Molecular Endocrinology reports. Stem cells control organ homeostasis, growth, and self-regulation. This is done by relying on a network of short-range, localized transcription factors (TFs). Transcription factors are a major effector of physiological changes and wield significant influence on stem cell behavior in many ways.