Tunicamycin: ER Stress Inducer When we hear the terms cell death and endoplasmic reticulum (ER) stress, what first comes to mind? 3D illustration of protein folding Stress? Death? Two concepts that don’t exactly inspire positive thoughts. However, in the case of the antibiotic compound tunicamycin, cell death and ER stress are the objectives. What is Tunicamycin? Tunicamycin is an antibiotic...
One of our most popular antibiotics, anisomycin, is a protein and DNA synthesis inhibitor that specializes in inhibiting the 80S ribosome network (eukaryotes). Anisomycinâ€™s properties of inhibition become activated when concentrations are enough to effect greater than 95% of the 80S ribosome protein synthesis. Additionally, Anisomycin works by activating the stress response via the MAP kinase signal transduction pathway.