Valinomycin is a potent antibiotic which acts as a potassium (K+) ionophore. Induces K+ conductivity in cell membranes. Also active in vitro against Mycobacterium Tuberculosis, and as an apoptosis inducer. Valinomycin is obtained from the cells of several Streptomyces strains, among which "S. tsusimaensis" and S. fulvissimus.
One of our most popular antibiotics, anisomycin, is a protein and DNA synthesis inhibitor that specializes in inhibiting the 80S ribosome network (eukaryotes). Anisomycinâ€™s properties of inhibition become activated when concentrations are enough to effect greater than 95% of the 80S ribosome protein synthesis. Additionally, Anisomycin works by activating the stress response via the MAP kinase signal transduction pathway.
The ionophores were first recognized as being a separate class with the publication of the structure for monensin in 1967. Several members of the group have found commercial application as anticoccidials in poultry farming and as growth promoters for cattle, pigs and chickens.