Bongkrekate; Bongkreksaure; Flavotoxin A; heptaenedioic acid; Bongkrekic acid triammonium salt; Bongkrekic acid (ammonium salt); 3-Carboxymethyl-17-methoxy-6,18,21-trimethyldocosa-2,4,8,12,18,20-heptaenedioic acid, triammonium salt
Soluble in DMSO. Dilute with destilled water or buffer, pH 7.0-7.5
Reconstitute to 1 mg/ml with distilled water
Bongkrekic acid is an antiapoptotic agent. (1) This compound protects against NMDA receptor induced neuronal apoptosis (2) It extends cell survival in cells undergoing apoptosis following infection with viral vectors and abrogated apoptosis induced by hydrogen peroxide in T-cells. (3) Bongkrekic acid is an inhibitor of adenine nucleotide translocase, which is a component of the Mitochondrial Permeability Transition (MPT) pore complex. Thus, it prevents mitochondrial depolarization, swelling, rupture of mitochondria outer membrane, and release of apoptogenic proteins such as Cytochrome c.
Avoid contact with skin, eyes or clothing. Use personal protective equipment as required.
Wash contaminated clothing before reuse. Do not breathe dust/fume/gas/mist/vapors/spray.
Do not eat, drink or smoke when using this product.
Apoptotic Action of Peroxisome Proliferator-Activated Receptor-Activation in Human Non–Small-Cell Lung Cancer Is Mediated via Proline Oxidase-Induced Reactive Oxygen Species Formation
Ki Young Kim, Jin Hee Ahn, and Hyae Gyeong Cheon
Mol. Pharmacol., Sep 2007; 72: 674 - 685.
Certificate of Analysis 1
Certificate of Analysis 2
Certificate of Analysis 3